Cargando…

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis

Objective: Aberrations in the PI3K/AKT/mTOR survival pathway in many cancers are the most common genomic abnormalities. The phytochemical and bioactive agent sulforaphane (SFN) has nutrigenomic potential in activating the expression of several cellular protective genes via the transcription factor n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mokhtari, Reza Bayat, Qorri, Bessi, Baluch, Narges, Sparaneo, Angelo, Fabrizio, Federico Pio, Muscarella, Lucia Anna, Tyker, Albina, Kumar, Sushil, Cheng, Hai-Ling Margaret, Szewczuk, Myron R., Das, Bikul, Yeger, Herman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310668/ https://www.ncbi.nlm.nih.gov/pubmed/34316328 http://dx.doi.org/10.18632/oncotarget.28011

Ejemplares similares

Correction: Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis
por: Mokhtari, Reza Bayat, et al.
Publicado: (2022)

Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane
por: Bayat Mokhtari, Reza, et al.
Publicado: (2019)

Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines
por: Mokhtari, Reza Bayat, et al.
Publicado: (2013)

3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model
por: Mokhtari, Reza Bayat, et al.
Publicado: (2021)

The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy
por: Mokhtari, Reza Bayat, et al.
Publicado: (2021)

Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma
por: Bayat Mokhtari, Reza, et al.
Publicado: (2017)

Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression
por: Qorri, Bessi, et al.
Publicado: (2022)

Repositioning of Old Drugs for Novel Cancer Therapies: Continuous Therapeutic Perfusion of Aspirin and Oseltamivir Phosphate with Gemcitabine Treatment Disables Tumor Progression, Chemoresistance, and Metastases
por: Qorri, Bessi, et al.
Publicado: (2022)

Combination therapy in combating cancer
por: Mokhtari, Reza Bayat, et al.
Publicado: (2017)

The crucial role of primary care providers in the long-term follow-up of adult survivors of childhood cancer
por: Jain, Justin, et al.
Publicado: (2019)

Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells
por: Qorri, Bessi, et al.
Publicado: (2020)

Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
por: Liauchonak, Iryna, et al.
Publicado: (2019)

Recent advances in “smart” delivery systems for extended drug release in cancer therapy
por: Kalaydina, Regina-Veronicka, et al.
Publicado: (2018)

Novel Therapeutic Target Critical for SARS-CoV-2 Infectivity and Induction of the Cytokine Release Syndrome
por: Harless, William W., et al.
Publicado: (2023)

Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling
por: Qorri, Bessi, et al.
Publicado: (2018)

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
por: Houghton, Christine A., et al.
Publicado: (2016)

The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment
por: Mokhtari, Reza Bayat, et al.
Publicado: (2023)

HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells
por: Das, Bikul, et al.
Publicado: (2012)

Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity
por: Sambi, Manpreet, et al.
Publicado: (2017)

A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer
por: Sambi, Manpreet, et al.
Publicado: (2020)

Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad
por: Sparaneo, Angelo, et al.
Publicado: (2016)

NRF2 Regulation by Noncoding RNAs in Cancers: The Present Knowledge and the Way Forward
por: Fabrizio, Federico Pio, et al.
Publicado: (2020)

Monitoring EGFR-lung cancer evolution: a possible beginning of a “methylation era” in TKI resistance prediction
por: Fabrizio, Federico Pio, et al.
Publicado: (2023)

Therapeutic potential of medicinal marijuana: an educational primer for health care professionals
por: Mouhamed, Yara, et al.
Publicado: (2018)

Management of bronchial carcinoid: An anaesthetic challenge
por: Gupta, Prasoon, et al.
Publicado: (2014)

Pleural Metastasis of Atypical Bronchial Carcinoid
por: Zinchenko, Eugeniy Igorevich, et al.
Publicado: (2020)

Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
por: Parente, Paola, et al.
Publicado: (2021)

The Biased G-Protein-Coupled Receptor Agonism Bridges the Gap between the Insulin Receptor and the Metabolic Syndrome
por: Liauchonak, Iryna, et al.
Publicado: (2018)

Metastasizing Bronchial Adenoma with Associated Carcinoid Syndrome
por: Sacks, M. I., et al.
Publicado: (1961)

Bronchial carcinoid tumor: A case report
por: Mindaye, Esubalew Taddese, et al.
Publicado: (2020)

Cushing’s like syndrome in typical bronchial carcinoid a case report and review of the literature
por: Pedicelli, Ilaria, et al.
Publicado: (2016)

Nutrigenomics and Cancer
por: Ardekani, Ali M., et al.
Publicado: (2009)

Nutrigenomics and Nutrigenetics
por: Farhud, DD, et al.
Publicado: (2010)

Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics
por: Klotz, Lars-Oliver, et al.
Publicado: (2023)

Epigenetic Scanning of KEAP1 CpG Sites Uncovers New Molecular-Driven Patterns in Lung Adeno and Squamous Cell Carcinomas
por: Fabrizio, Federico Pio, et al.
Publicado: (2020)

Bronchial Carcinoids: From Molecular Background to Treatment Approach
por: Araujo-Castro, Marta, et al.
Publicado: (2022)

Spontaneous massive hemothorax as an atypical presentation of bronchial carcinoid
por: Çelik, Burçin, et al.
Publicado: (2022)

A Multimodal Biomarker Predicts Dissemination of Bronchial Carcinoid
por: Reuling, Ellen M. B. P., et al.
Publicado: (2022)

Atypical Bronchial Carcinoid Tumor Revealed by Liver Biopsy
por: Hayoune, Amine, et al.
Publicado: (2022)

Nutrigenetics, Nutrigenomics, and Selenium
por: Ferguson, Lynnette R., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8qk93k383762t4qigmfs82q0ug