Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4(+) T cells in primary sclerosing cholangitis

BACKGROUND & AIMS: Little is known about the composition of intrahepatic immune cells and their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). Herein, we aimed to create an atlas of intrahepatic T cells and thereby perform an in-depth characterization of T cells in inf...

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Detalles Bibliográficos
Autores principales: Poch, Tobias, Krause, Jenny, Casar, Christian, Liwinski, Timur, Glau, Laura, Kaufmann, Max, Ahrenstorf, Annika E., Hess, Leonard U., Ziegler, Annerose E., Martrus, Glòria, Lunemann, Sebastian, Sebode, Marcial, Li, Jun, Schwinge, Dorothee, Krebs, Christian F., Franke, Andre, Friese, Manuel A., Oldhafer, Karl J., Fischer, Lutz, Altfeld, Marcus, Lohse, Ansgar W., Huber, Samuel, Tolosa, Eva, Gagliani, Nicola, Schramm, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310924/
https://www.ncbi.nlm.nih.gov/pubmed/33774059
http://dx.doi.org/10.1016/j.jhep.2021.03.016

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