Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations

Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogen...

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Detalles Bibliográficos
Autores principales: Mahajan, Asha M., Itan, Yuval, Cerrone, Marina, Horowitz, James, Borneman, Linda, Chinitz, Larry, Jankelson, Lior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Mini-Focus Issue: Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310969/
https://www.ncbi.nlm.nih.gov/pubmed/34317510
http://dx.doi.org/10.1016/j.jaccas.2020.11.046
Descripción
Sumario:Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogenesis in Bi-MVP patients. (Level of Difficulty: Intermediate.)

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