Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations

Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogen...

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Detalles Bibliográficos
Autores principales: Mahajan, Asha M., Itan, Yuval, Cerrone, Marina, Horowitz, James, Borneman, Linda, Chinitz, Larry, Jankelson, Lior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Mini-Focus Issue: Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310969/
https://www.ncbi.nlm.nih.gov/pubmed/34317510
http://dx.doi.org/10.1016/j.jaccas.2020.11.046
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author Mahajan, Asha M.
Itan, Yuval
Cerrone, Marina
Horowitz, James
Borneman, Linda
Chinitz, Larry
Jankelson, Lior
author_facet Mahajan, Asha M.
Itan, Yuval
Cerrone, Marina
Horowitz, James
Borneman, Linda
Chinitz, Larry
Jankelson, Lior
author_sort Mahajan, Asha M.
collection PubMed
description Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogenesis in Bi-MVP patients. (Level of Difficulty: Intermediate.)
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spelling pubmed-83109692021-07-26 Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations Mahajan, Asha M. Itan, Yuval Cerrone, Marina Horowitz, James Borneman, Linda Chinitz, Larry Jankelson, Lior JACC Case Rep Mini-Focus Issue: Imaging Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogenesis in Bi-MVP patients. (Level of Difficulty: Intermediate.) Elsevier 2021-02-17 /pmc/articles/PMC8310969/ /pubmed/34317510 http://dx.doi.org/10.1016/j.jaccas.2020.11.046 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Focus Issue: Imaging
Mahajan, Asha M.
Itan, Yuval
Cerrone, Marina
Horowitz, James
Borneman, Linda
Chinitz, Larry
Jankelson, Lior
Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
title Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
title_full Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
title_fullStr Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
title_full_unstemmed Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
title_short Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
title_sort sudden cardiac arrest in a patient with mitral valve prolapse and lmna and scn5a mutations
topic Mini-Focus Issue: Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310969/
https://www.ncbi.nlm.nih.gov/pubmed/34317510
http://dx.doi.org/10.1016/j.jaccas.2020.11.046
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