Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient

Currently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type tra...

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Autores principales: Vergaro, Giuseppe, Castiglione, Vincenzo, Poletti, Roberta, Buda, Gabriele, Pucci, Angela, Musetti, Veronica, Genovesi, Dario, Aimo, Alberto, Passino, Claudio, Emdin, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Mini-Focus Issue: Heart Failure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311035/
https://www.ncbi.nlm.nih.gov/pubmed/34317556
http://dx.doi.org/10.1016/j.jaccas.2020.12.047
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author Vergaro, Giuseppe
Castiglione, Vincenzo
Poletti, Roberta
Buda, Gabriele
Pucci, Angela
Musetti, Veronica
Genovesi, Dario
Aimo, Alberto
Passino, Claudio
Emdin, Michele
author_facet Vergaro, Giuseppe
Castiglione, Vincenzo
Poletti, Roberta
Buda, Gabriele
Pucci, Angela
Musetti, Veronica
Genovesi, Dario
Aimo, Alberto
Passino, Claudio
Emdin, Michele
author_sort Vergaro, Giuseppe
collection PubMed
description Currently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type transthyretin amyloidosis and light-chain cardiac amyloidosis cardiomyopathy over a 3-year timespan. (Level of Difficulty: Intermediate.)
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spelling pubmed-83110352021-07-26 Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient Vergaro, Giuseppe Castiglione, Vincenzo Poletti, Roberta Buda, Gabriele Pucci, Angela Musetti, Veronica Genovesi, Dario Aimo, Alberto Passino, Claudio Emdin, Michele JACC Case Rep Mini-Focus Issue: Heart Failure Currently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type transthyretin amyloidosis and light-chain cardiac amyloidosis cardiomyopathy over a 3-year timespan. (Level of Difficulty: Intermediate.) Elsevier 2021-03-17 /pmc/articles/PMC8311035/ /pubmed/34317556 http://dx.doi.org/10.1016/j.jaccas.2020.12.047 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Focus Issue: Heart Failure
Vergaro, Giuseppe
Castiglione, Vincenzo
Poletti, Roberta
Buda, Gabriele
Pucci, Angela
Musetti, Veronica
Genovesi, Dario
Aimo, Alberto
Passino, Claudio
Emdin, Michele
Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_full Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_fullStr Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_full_unstemmed Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_short Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_sort biopsy evidence of sequential transthyretin and immunoglobulin light-chain cardiac amyloidosis in the same patient
topic Mini-Focus Issue: Heart Failure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311035/
https://www.ncbi.nlm.nih.gov/pubmed/34317556
http://dx.doi.org/10.1016/j.jaccas.2020.12.047
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