Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm

Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment. Repurposing riociguat, a soluble guanylate cycla...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez Pereyra, Valeria, Seitz, Andreas, Hubert, Astrid, Beck, Sascha, Hofmann, Ute, Schwab, Matthias, Bekeredjian, Raffi, Sechtem, Udo, Ong, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Mini-Focus Issue: Coronary & Structural Interventions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311038/
https://www.ncbi.nlm.nih.gov/pubmed/34317544
http://dx.doi.org/10.1016/j.jaccas.2020.11.043
_version_ 1783728880547266560
author Martínez Pereyra, Valeria
Seitz, Andreas
Hubert, Astrid
Beck, Sascha
Hofmann, Ute
Schwab, Matthias
Bekeredjian, Raffi
Sechtem, Udo
Ong, Peter
author_facet Martínez Pereyra, Valeria
Seitz, Andreas
Hubert, Astrid
Beck, Sascha
Hofmann, Ute
Schwab, Matthias
Bekeredjian, Raffi
Sechtem, Udo
Ong, Peter
author_sort Martínez Pereyra, Valeria
collection PubMed
description Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment. Repurposing riociguat, a soluble guanylate cyclase stimulator, resulted in improvement of symptoms and prevention of spasm. (Level of Difficulty: Intermediate.)
format Online
Article
Text
id pubmed-8311038
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83110382021-07-26 Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm Martínez Pereyra, Valeria Seitz, Andreas Hubert, Astrid Beck, Sascha Hofmann, Ute Schwab, Matthias Bekeredjian, Raffi Sechtem, Udo Ong, Peter JACC Case Rep Mini-Focus Issue: Coronary & Structural Interventions Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment. Repurposing riociguat, a soluble guanylate cyclase stimulator, resulted in improvement of symptoms and prevention of spasm. (Level of Difficulty: Intermediate.) Elsevier 2021-02-24 /pmc/articles/PMC8311038/ /pubmed/34317544 http://dx.doi.org/10.1016/j.jaccas.2020.11.043 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Focus Issue: Coronary & Structural Interventions
Martínez Pereyra, Valeria
Seitz, Andreas
Hubert, Astrid
Beck, Sascha
Hofmann, Ute
Schwab, Matthias
Bekeredjian, Raffi
Sechtem, Udo
Ong, Peter
Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
title Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
title_full Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
title_fullStr Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
title_full_unstemmed Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
title_short Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
title_sort repurposing riociguat for treatment of refractory angina resulting from coronary spasm
topic Mini-Focus Issue: Coronary & Structural Interventions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311038/
https://www.ncbi.nlm.nih.gov/pubmed/34317544
http://dx.doi.org/10.1016/j.jaccas.2020.11.043
work_keys_str_mv AT martinezpereyravaleria repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT seitzandreas repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT hubertastrid repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT becksascha repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT hofmannute repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT schwabmatthias repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT bekeredjianraffi repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT sechtemudo repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm
AT ongpeter repurposingriociguatfortreatmentofrefractoryanginaresultingfromcoronaryspasm

Ejemplares similares