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Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy

BACKGROUND: Limited studies have identified the changes in peripapillary retinal nerve fibre layer (pRNFL) thickness in patients with chronic Leber’s hereditary optic neuropathy (LHON) at different stages of the disease. We aimed to characterise the pRNFL thickness changes in patients with LHON havi...

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Autores principales: Wang, Dan, Liu, Hong-Li, Du, Yang-Yang, Yuan, Jiajia, Li, Xin, Tian, Zhen, Zhou, Haiqiang, Wang, Shuang, Song, Lin, Sun, Jian, Xiao, Xiao, Wang, Zhi-Tao, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311077/
https://www.ncbi.nlm.nih.gov/pubmed/32862131
http://dx.doi.org/10.1136/bjophthalmol-2020-316573
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author Wang, Dan
Liu, Hong-Li
Du, Yang-Yang
Yuan, Jiajia
Li, Xin
Tian, Zhen
Zhou, Haiqiang
Wang, Shuang
Song, Lin
Sun, Jian
Xiao, Xiao
Wang, Zhi-Tao
Li, Bin
author_facet Wang, Dan
Liu, Hong-Li
Du, Yang-Yang
Yuan, Jiajia
Li, Xin
Tian, Zhen
Zhou, Haiqiang
Wang, Shuang
Song, Lin
Sun, Jian
Xiao, Xiao
Wang, Zhi-Tao
Li, Bin
author_sort Wang, Dan
collection PubMed
description BACKGROUND: Limited studies have identified the changes in peripapillary retinal nerve fibre layer (pRNFL) thickness in patients with chronic Leber’s hereditary optic neuropathy (LHON) at different stages of the disease. We aimed to characterise the pRNFL thickness changes in patients with LHON having m.11778G>A (MT-ND4) mutation. METHODS: This retrospective cross-sectional study included 221 eyes from patients with LHON (n=145)—classified into seven groups according to disease duration—and 52 eyes from healthy controls (n=26). All subjects underwent pRNFL examinations. pRNFL thickness of the superior, nasal and inferior, and temporal quadrants, and the 360° average were measured. RESULTS: Within 3 months of onset, the temporal pRNFL thickness decreased significantly, whereas the remaining quadrants and the average pRNFL thickness initially increased. The temporal quadrant (p<0.01) and average pRNFL thickness (p=0.02) significantly decreased at 3–6 months. Excluding that in the nasal quadrant (p=0.93), pRNFL thickness significantly decreased in all other quadrants at 6–9 months. At 9–12 months, the average and individual quadrant pRNFL thicknesses continued to decrease. Compared with 12–24 months, the pRNFL thickness was thinner at 24–60 months and >60 months. CONCLUSIONS: The papillomacular bundle was affected first and preferentially in LHON. pRNFL thickness initially increased and then decreased, corresponding to the retinal ganglion cell swelling and apoptosis. pRNFL thinning first occurred in the temporal quadrant, followed by the inferior and superior quadrants, and finally, the nasal quadrant. pRNFL continued to thin slowly in some quadrants even after 60 months.
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spelling pubmed-83110772021-08-13 Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy Wang, Dan Liu, Hong-Li Du, Yang-Yang Yuan, Jiajia Li, Xin Tian, Zhen Zhou, Haiqiang Wang, Shuang Song, Lin Sun, Jian Xiao, Xiao Wang, Zhi-Tao Li, Bin Br J Ophthalmol Clinical Science BACKGROUND: Limited studies have identified the changes in peripapillary retinal nerve fibre layer (pRNFL) thickness in patients with chronic Leber’s hereditary optic neuropathy (LHON) at different stages of the disease. We aimed to characterise the pRNFL thickness changes in patients with LHON having m.11778G>A (MT-ND4) mutation. METHODS: This retrospective cross-sectional study included 221 eyes from patients with LHON (n=145)—classified into seven groups according to disease duration—and 52 eyes from healthy controls (n=26). All subjects underwent pRNFL examinations. pRNFL thickness of the superior, nasal and inferior, and temporal quadrants, and the 360° average were measured. RESULTS: Within 3 months of onset, the temporal pRNFL thickness decreased significantly, whereas the remaining quadrants and the average pRNFL thickness initially increased. The temporal quadrant (p<0.01) and average pRNFL thickness (p=0.02) significantly decreased at 3–6 months. Excluding that in the nasal quadrant (p=0.93), pRNFL thickness significantly decreased in all other quadrants at 6–9 months. At 9–12 months, the average and individual quadrant pRNFL thicknesses continued to decrease. Compared with 12–24 months, the pRNFL thickness was thinner at 24–60 months and >60 months. CONCLUSIONS: The papillomacular bundle was affected first and preferentially in LHON. pRNFL thickness initially increased and then decreased, corresponding to the retinal ganglion cell swelling and apoptosis. pRNFL thinning first occurred in the temporal quadrant, followed by the inferior and superior quadrants, and finally, the nasal quadrant. pRNFL continued to thin slowly in some quadrants even after 60 months. BMJ Publishing Group 2021-08 2020-08-31 /pmc/articles/PMC8311077/ /pubmed/32862131 http://dx.doi.org/10.1136/bjophthalmol-2020-316573 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Clinical Science
Wang, Dan
Liu, Hong-Li
Du, Yang-Yang
Yuan, Jiajia
Li, Xin
Tian, Zhen
Zhou, Haiqiang
Wang, Shuang
Song, Lin
Sun, Jian
Xiao, Xiao
Wang, Zhi-Tao
Li, Bin
Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy
title Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy
title_full Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy
title_fullStr Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy
title_full_unstemmed Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy
title_short Characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with Leber’s hereditary optic neuropathy
title_sort characterisation of thickness changes in the peripapillary retinal nerve fibre layer in patients with leber’s hereditary optic neuropathy
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311077/
https://www.ncbi.nlm.nih.gov/pubmed/32862131
http://dx.doi.org/10.1136/bjophthalmol-2020-316573
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