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Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity

Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is up...

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Autores principales: Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Goel, Swati, Mahboub, Bassam, Ansari, Abdul Wahid, Temsah, Mohamad-Hani, Zakri, Adel M., Ratemi, Elaref, Hamoudi, Rifat, Hamid, Qutayba, Halwani, Rabih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311130/
https://www.ncbi.nlm.nih.gov/pubmed/34322544
http://dx.doi.org/10.1183/23120541.00984-2020
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author Saheb Sharif-Askari, Fatemeh
Saheb Sharif-Askari, Narjes
Goel, Swati
Mahboub, Bassam
Ansari, Abdul Wahid
Temsah, Mohamad-Hani
Zakri, Adel M.
Ratemi, Elaref
Hamoudi, Rifat
Hamid, Qutayba
Halwani, Rabih
author_facet Saheb Sharif-Askari, Fatemeh
Saheb Sharif-Askari, Narjes
Goel, Swati
Mahboub, Bassam
Ansari, Abdul Wahid
Temsah, Mohamad-Hani
Zakri, Adel M.
Ratemi, Elaref
Hamoudi, Rifat
Hamid, Qutayba
Halwani, Rabih
author_sort Saheb Sharif-Askari, Fatemeh
collection PubMed
description Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target.
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spelling pubmed-83111302021-07-27 Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Goel, Swati Mahboub, Bassam Ansari, Abdul Wahid Temsah, Mohamad-Hani Zakri, Adel M. Ratemi, Elaref Hamoudi, Rifat Hamid, Qutayba Halwani, Rabih ERJ Open Res Original Research Articles Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target. European Respiratory Society 2021-07-26 /pmc/articles/PMC8311130/ /pubmed/34322544 http://dx.doi.org/10.1183/23120541.00984-2020 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Articles
Saheb Sharif-Askari, Fatemeh
Saheb Sharif-Askari, Narjes
Goel, Swati
Mahboub, Bassam
Ansari, Abdul Wahid
Temsah, Mohamad-Hani
Zakri, Adel M.
Ratemi, Elaref
Hamoudi, Rifat
Hamid, Qutayba
Halwani, Rabih
Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
title Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
title_full Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
title_fullStr Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
title_full_unstemmed Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
title_short Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
title_sort upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311130/
https://www.ncbi.nlm.nih.gov/pubmed/34322544
http://dx.doi.org/10.1183/23120541.00984-2020
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