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Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is up...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311130/ https://www.ncbi.nlm.nih.gov/pubmed/34322544 http://dx.doi.org/10.1183/23120541.00984-2020 |
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author | Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Goel, Swati Mahboub, Bassam Ansari, Abdul Wahid Temsah, Mohamad-Hani Zakri, Adel M. Ratemi, Elaref Hamoudi, Rifat Hamid, Qutayba Halwani, Rabih |
author_facet | Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Goel, Swati Mahboub, Bassam Ansari, Abdul Wahid Temsah, Mohamad-Hani Zakri, Adel M. Ratemi, Elaref Hamoudi, Rifat Hamid, Qutayba Halwani, Rabih |
author_sort | Saheb Sharif-Askari, Fatemeh |
collection | PubMed |
description | Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target. |
format | Online Article Text |
id | pubmed-8311130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-83111302021-07-27 Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Goel, Swati Mahboub, Bassam Ansari, Abdul Wahid Temsah, Mohamad-Hani Zakri, Adel M. Ratemi, Elaref Hamoudi, Rifat Hamid, Qutayba Halwani, Rabih ERJ Open Res Original Research Articles Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target. European Respiratory Society 2021-07-26 /pmc/articles/PMC8311130/ /pubmed/34322544 http://dx.doi.org/10.1183/23120541.00984-2020 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original Research Articles Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Goel, Swati Mahboub, Bassam Ansari, Abdul Wahid Temsah, Mohamad-Hani Zakri, Adel M. Ratemi, Elaref Hamoudi, Rifat Hamid, Qutayba Halwani, Rabih Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
title | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
title_full | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
title_fullStr | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
title_full_unstemmed | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
title_short | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
title_sort | upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311130/ https://www.ncbi.nlm.nih.gov/pubmed/34322544 http://dx.doi.org/10.1183/23120541.00984-2020 |
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