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Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy
BACKGROUND: Iatrogenic pneumothorax is a common and clinically important transbronchial cryobiopsy (TBCB) complication. A study was conducted to assess the diagnostic accuracy and clinical impact of immediate post-procedure lung ultrasound for diagnosing iatrogenic pneumothorax in patients suspected...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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European Respiratory Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311132/ https://www.ncbi.nlm.nih.gov/pubmed/34322546 http://dx.doi.org/10.1183/23120541.00045-2021 |
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author | Laursen, Christian B. Pietersen, Pia I. Jacobsen, Niels Falster, Casper Juul, Amanda D. Davidsen, Jesper R. |
author_facet | Laursen, Christian B. Pietersen, Pia I. Jacobsen, Niels Falster, Casper Juul, Amanda D. Davidsen, Jesper R. |
author_sort | Laursen, Christian B. |
collection | PubMed |
description | BACKGROUND: Iatrogenic pneumothorax is a common and clinically important transbronchial cryobiopsy (TBCB) complication. A study was conducted to assess the diagnostic accuracy and clinical impact of immediate post-procedure lung ultrasound for diagnosing iatrogenic pneumothorax in patients suspected of interstitial lung disease (ILD) undergoing TBCB. STUDY DESIGN AND METHODS: In patients undergoing TBCB due to suspected ILD, lung ultrasound of the anterior surface of the chest was performed immediately after the TBCB procedure prior to extubation. Presence of lung point was used as a definite sign of pneumothorax. Chest radiography was routinely performed 2 h after TBCB and was used as the reference standard. RESULTS: A total of 141 consecutive patients were included. Post-procedure lung ultrasound identified definite pneumothorax in five patients (3.6%, 95% confidence interval (CI) 1.5–8.3%). Chest radiography at 2 h identified 19 patients (13.5%, 95% CI 8.7–20.2%) with pneumothorax following TBCB. The diagnostic accuracy of lung ultrasound for diagnosing pneumothorax was as follows: sensitivity: 21.1% (95% CI 6.1–45.6%), specificity: 99.2% (95% CI 95.5–100.0%), positive predictive value (PPV): 80.0% (95% CI 28.4–99.5%) and negative predictive value (NPV): 89.0% (95% CI 82.5–93.7%). Post-procedure lung ultrasound had a clinical impact in five patients (3.6%, 95% CI 1.5–8.3), of which four had a pleural drain inserted prior to extubation and one underwent prolonged observation prior to extubation. INTERPRETATION: Lung ultrasound performed immediately following TBCB has a clinical impact by identifying patients with pneumothorax in need of immediate treatment prior to extubation and by monitoring pneumothorax size in the operating room. Supplementary imaging prior to patient discharge is still needed however, as the majority of pneumothoraxes develop later in the post-procedure period. |
format | Online Article Text |
id | pubmed-8311132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-83111322021-07-27 Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy Laursen, Christian B. Pietersen, Pia I. Jacobsen, Niels Falster, Casper Juul, Amanda D. Davidsen, Jesper R. ERJ Open Res Original Research Articles BACKGROUND: Iatrogenic pneumothorax is a common and clinically important transbronchial cryobiopsy (TBCB) complication. A study was conducted to assess the diagnostic accuracy and clinical impact of immediate post-procedure lung ultrasound for diagnosing iatrogenic pneumothorax in patients suspected of interstitial lung disease (ILD) undergoing TBCB. STUDY DESIGN AND METHODS: In patients undergoing TBCB due to suspected ILD, lung ultrasound of the anterior surface of the chest was performed immediately after the TBCB procedure prior to extubation. Presence of lung point was used as a definite sign of pneumothorax. Chest radiography was routinely performed 2 h after TBCB and was used as the reference standard. RESULTS: A total of 141 consecutive patients were included. Post-procedure lung ultrasound identified definite pneumothorax in five patients (3.6%, 95% confidence interval (CI) 1.5–8.3%). Chest radiography at 2 h identified 19 patients (13.5%, 95% CI 8.7–20.2%) with pneumothorax following TBCB. The diagnostic accuracy of lung ultrasound for diagnosing pneumothorax was as follows: sensitivity: 21.1% (95% CI 6.1–45.6%), specificity: 99.2% (95% CI 95.5–100.0%), positive predictive value (PPV): 80.0% (95% CI 28.4–99.5%) and negative predictive value (NPV): 89.0% (95% CI 82.5–93.7%). Post-procedure lung ultrasound had a clinical impact in five patients (3.6%, 95% CI 1.5–8.3), of which four had a pleural drain inserted prior to extubation and one underwent prolonged observation prior to extubation. INTERPRETATION: Lung ultrasound performed immediately following TBCB has a clinical impact by identifying patients with pneumothorax in need of immediate treatment prior to extubation and by monitoring pneumothorax size in the operating room. Supplementary imaging prior to patient discharge is still needed however, as the majority of pneumothoraxes develop later in the post-procedure period. European Respiratory Society 2021-07-26 /pmc/articles/PMC8311132/ /pubmed/34322546 http://dx.doi.org/10.1183/23120541.00045-2021 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original Research Articles Laursen, Christian B. Pietersen, Pia I. Jacobsen, Niels Falster, Casper Juul, Amanda D. Davidsen, Jesper R. Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
title | Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
title_full | Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
title_fullStr | Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
title_full_unstemmed | Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
title_short | Lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
title_sort | lung ultrasound assessment for pneumothorax following transbronchial lung cryobiopsy |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311132/ https://www.ncbi.nlm.nih.gov/pubmed/34322546 http://dx.doi.org/10.1183/23120541.00045-2021 |
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