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Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
OBJECTIVES: A significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311439/ https://www.ncbi.nlm.nih.gov/pubmed/34322385 http://dx.doi.org/10.3389/fonc.2021.683825 |
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author | Li, Jiajia Liu, Shan Li, Zhangao Han, Xinxin Que, Lin |
author_facet | Li, Jiajia Liu, Shan Li, Zhangao Han, Xinxin Que, Lin |
author_sort | Li, Jiajia |
collection | PubMed |
description | OBJECTIVES: A significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI. MATERIALS AND METHODS: PubMed, Embase, and the Cochrane Library were queried for potentially eligible articles published up to December 2020. The primary outcomes were the hazard ratio (HR) for locoregional recurrence, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The random-effect model was used in all analyses. RESULTS: Seventeen studies (4445 patients) were included. Using adjusted HRs, the presence of PNI was associated with a higher risk of locoregional recurrence (HR=1.73, 95%CI: 1.07-2.79, P=0.025, I(2) = 33.1%, P(heterogeneity)=0.224), worse OS (HR=1.94, 95%CI: 1.39-2.72, P<0.001, I(2) = 0.0%, P(heterogeneity)=0.838), worse DFS (HR=2.13, 95%CI: 1.53-2.96, P<0.001, I(2) = 48.4%, P(heterogeneity)=0.071), and worse CSS (HR=1.93, 95%CI: 1.40-2.65, P<0.001, I(2) = 25.5%, P(heterogeneity)=0.251). PNI had an impact on locoregional recurrence in early-stage OTSCC but not in all stages, and on OS, DFS, and CSS in all-stage and early-stage OTSCC. The sensitivity analyses showed that the results were robust. CONCLUSION: The presence of PNI significantly affects the locoregional recurrence and survival outcomes among patients with OTSCC. |
format | Online Article Text |
id | pubmed-8311439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83114392021-07-27 Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis Li, Jiajia Liu, Shan Li, Zhangao Han, Xinxin Que, Lin Front Oncol Oncology OBJECTIVES: A significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI. MATERIALS AND METHODS: PubMed, Embase, and the Cochrane Library were queried for potentially eligible articles published up to December 2020. The primary outcomes were the hazard ratio (HR) for locoregional recurrence, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The random-effect model was used in all analyses. RESULTS: Seventeen studies (4445 patients) were included. Using adjusted HRs, the presence of PNI was associated with a higher risk of locoregional recurrence (HR=1.73, 95%CI: 1.07-2.79, P=0.025, I(2) = 33.1%, P(heterogeneity)=0.224), worse OS (HR=1.94, 95%CI: 1.39-2.72, P<0.001, I(2) = 0.0%, P(heterogeneity)=0.838), worse DFS (HR=2.13, 95%CI: 1.53-2.96, P<0.001, I(2) = 48.4%, P(heterogeneity)=0.071), and worse CSS (HR=1.93, 95%CI: 1.40-2.65, P<0.001, I(2) = 25.5%, P(heterogeneity)=0.251). PNI had an impact on locoregional recurrence in early-stage OTSCC but not in all stages, and on OS, DFS, and CSS in all-stage and early-stage OTSCC. The sensitivity analyses showed that the results were robust. CONCLUSION: The presence of PNI significantly affects the locoregional recurrence and survival outcomes among patients with OTSCC. Frontiers Media S.A. 2021-07-12 /pmc/articles/PMC8311439/ /pubmed/34322385 http://dx.doi.org/10.3389/fonc.2021.683825 Text en Copyright © 2021 Li, Liu, Li, Han and Que https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Jiajia Liu, Shan Li, Zhangao Han, Xinxin Que, Lin Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
title | Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
title_full | Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
title_fullStr | Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
title_short | Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
title_sort | prognostic value of perineural invasion in oral tongue squamous cell carcinoma: a systematic review and meta-analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311439/ https://www.ncbi.nlm.nih.gov/pubmed/34322385 http://dx.doi.org/10.3389/fonc.2021.683825 |
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