Cargando…

Impact of SARS-CoV-2 on neuropsychiatric disorders

Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headach...

Descripción completa

Detalles Bibliográficos
Autores principales: Robinson-Agramonte, Maria de los Angeles, Gonçalves, Carlos-Alberto, Noris-García, Elena, Préndes Rivero, Naybí, Brigida, Anna Lisa, Schultz, Stephen, Siniscalco, Dario, García García, Ramiro Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311516/
https://www.ncbi.nlm.nih.gov/pubmed/34327127
http://dx.doi.org/10.5498/wjp.v11.i7.347
_version_ 1783728972899549184
author Robinson-Agramonte, Maria de los Angeles
Gonçalves, Carlos-Alberto
Noris-García, Elena
Préndes Rivero, Naybí
Brigida, Anna Lisa
Schultz, Stephen
Siniscalco, Dario
García García, Ramiro Jorge
author_facet Robinson-Agramonte, Maria de los Angeles
Gonçalves, Carlos-Alberto
Noris-García, Elena
Préndes Rivero, Naybí
Brigida, Anna Lisa
Schultz, Stephen
Siniscalco, Dario
García García, Ramiro Jorge
author_sort Robinson-Agramonte, Maria de los Angeles
collection PubMed
description Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headache, as well as others. Based on the high number of series of cases reported, there is evidence for the implication of the immune system in the pathological mechanism of COVID-19. Although the exact role of the immunological mechanism is not elucidated, two main mechanisms are suggested which implicate the direct effect of severe acute respiratory syndrome coronavirus 2 infection in the central nervous system and neuroinflammation. In the context of neurological manifestations associated with COVID-19, neuropsychiatric disorders show an exacerbation and are described by symptoms and signs such as depression, anxiety, mood alterations, psychosis, post-traumatic stress disorder, delirium, and cognitive impairment, which appear to be common in COVID-19 survivors. A worsened score on psychopathological measures is seen in those with a history of psychiatric comorbidities. We review the neuropsychiatric manifestations associated with COVID-19 and some critical aspects of the innate and adaptive immune system involved in mental health disorders occurring in COVID-19.
format Online
Article
Text
id pubmed-8311516
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-83115162021-07-28 Impact of SARS-CoV-2 on neuropsychiatric disorders Robinson-Agramonte, Maria de los Angeles Gonçalves, Carlos-Alberto Noris-García, Elena Préndes Rivero, Naybí Brigida, Anna Lisa Schultz, Stephen Siniscalco, Dario García García, Ramiro Jorge World J Psychiatry Minireviews Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headache, as well as others. Based on the high number of series of cases reported, there is evidence for the implication of the immune system in the pathological mechanism of COVID-19. Although the exact role of the immunological mechanism is not elucidated, two main mechanisms are suggested which implicate the direct effect of severe acute respiratory syndrome coronavirus 2 infection in the central nervous system and neuroinflammation. In the context of neurological manifestations associated with COVID-19, neuropsychiatric disorders show an exacerbation and are described by symptoms and signs such as depression, anxiety, mood alterations, psychosis, post-traumatic stress disorder, delirium, and cognitive impairment, which appear to be common in COVID-19 survivors. A worsened score on psychopathological measures is seen in those with a history of psychiatric comorbidities. We review the neuropsychiatric manifestations associated with COVID-19 and some critical aspects of the innate and adaptive immune system involved in mental health disorders occurring in COVID-19. Baishideng Publishing Group Inc 2021-07-19 /pmc/articles/PMC8311516/ /pubmed/34327127 http://dx.doi.org/10.5498/wjp.v11.i7.347 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Robinson-Agramonte, Maria de los Angeles
Gonçalves, Carlos-Alberto
Noris-García, Elena
Préndes Rivero, Naybí
Brigida, Anna Lisa
Schultz, Stephen
Siniscalco, Dario
García García, Ramiro Jorge
Impact of SARS-CoV-2 on neuropsychiatric disorders
title Impact of SARS-CoV-2 on neuropsychiatric disorders
title_full Impact of SARS-CoV-2 on neuropsychiatric disorders
title_fullStr Impact of SARS-CoV-2 on neuropsychiatric disorders
title_full_unstemmed Impact of SARS-CoV-2 on neuropsychiatric disorders
title_short Impact of SARS-CoV-2 on neuropsychiatric disorders
title_sort impact of sars-cov-2 on neuropsychiatric disorders
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311516/
https://www.ncbi.nlm.nih.gov/pubmed/34327127
http://dx.doi.org/10.5498/wjp.v11.i7.347
work_keys_str_mv AT robinsonagramontemariadelosangeles impactofsarscov2onneuropsychiatricdisorders
AT goncalvescarlosalberto impactofsarscov2onneuropsychiatricdisorders
AT norisgarciaelena impactofsarscov2onneuropsychiatricdisorders
AT prendesriveronaybi impactofsarscov2onneuropsychiatricdisorders
AT brigidaannalisa impactofsarscov2onneuropsychiatricdisorders
AT schultzstephen impactofsarscov2onneuropsychiatricdisorders
AT siniscalcodario impactofsarscov2onneuropsychiatricdisorders
AT garciagarciaramirojorge impactofsarscov2onneuropsychiatricdisorders