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Impact of SARS-CoV-2 on neuropsychiatric disorders
Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headach...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311516/ https://www.ncbi.nlm.nih.gov/pubmed/34327127 http://dx.doi.org/10.5498/wjp.v11.i7.347 |
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author | Robinson-Agramonte, Maria de los Angeles Gonçalves, Carlos-Alberto Noris-García, Elena Préndes Rivero, Naybí Brigida, Anna Lisa Schultz, Stephen Siniscalco, Dario García García, Ramiro Jorge |
author_facet | Robinson-Agramonte, Maria de los Angeles Gonçalves, Carlos-Alberto Noris-García, Elena Préndes Rivero, Naybí Brigida, Anna Lisa Schultz, Stephen Siniscalco, Dario García García, Ramiro Jorge |
author_sort | Robinson-Agramonte, Maria de los Angeles |
collection | PubMed |
description | Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headache, as well as others. Based on the high number of series of cases reported, there is evidence for the implication of the immune system in the pathological mechanism of COVID-19. Although the exact role of the immunological mechanism is not elucidated, two main mechanisms are suggested which implicate the direct effect of severe acute respiratory syndrome coronavirus 2 infection in the central nervous system and neuroinflammation. In the context of neurological manifestations associated with COVID-19, neuropsychiatric disorders show an exacerbation and are described by symptoms and signs such as depression, anxiety, mood alterations, psychosis, post-traumatic stress disorder, delirium, and cognitive impairment, which appear to be common in COVID-19 survivors. A worsened score on psychopathological measures is seen in those with a history of psychiatric comorbidities. We review the neuropsychiatric manifestations associated with COVID-19 and some critical aspects of the innate and adaptive immune system involved in mental health disorders occurring in COVID-19. |
format | Online Article Text |
id | pubmed-8311516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-83115162021-07-28 Impact of SARS-CoV-2 on neuropsychiatric disorders Robinson-Agramonte, Maria de los Angeles Gonçalves, Carlos-Alberto Noris-García, Elena Préndes Rivero, Naybí Brigida, Anna Lisa Schultz, Stephen Siniscalco, Dario García García, Ramiro Jorge World J Psychiatry Minireviews Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headache, as well as others. Based on the high number of series of cases reported, there is evidence for the implication of the immune system in the pathological mechanism of COVID-19. Although the exact role of the immunological mechanism is not elucidated, two main mechanisms are suggested which implicate the direct effect of severe acute respiratory syndrome coronavirus 2 infection in the central nervous system and neuroinflammation. In the context of neurological manifestations associated with COVID-19, neuropsychiatric disorders show an exacerbation and are described by symptoms and signs such as depression, anxiety, mood alterations, psychosis, post-traumatic stress disorder, delirium, and cognitive impairment, which appear to be common in COVID-19 survivors. A worsened score on psychopathological measures is seen in those with a history of psychiatric comorbidities. We review the neuropsychiatric manifestations associated with COVID-19 and some critical aspects of the innate and adaptive immune system involved in mental health disorders occurring in COVID-19. Baishideng Publishing Group Inc 2021-07-19 /pmc/articles/PMC8311516/ /pubmed/34327127 http://dx.doi.org/10.5498/wjp.v11.i7.347 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Robinson-Agramonte, Maria de los Angeles Gonçalves, Carlos-Alberto Noris-García, Elena Préndes Rivero, Naybí Brigida, Anna Lisa Schultz, Stephen Siniscalco, Dario García García, Ramiro Jorge Impact of SARS-CoV-2 on neuropsychiatric disorders |
title | Impact of SARS-CoV-2 on neuropsychiatric disorders |
title_full | Impact of SARS-CoV-2 on neuropsychiatric disorders |
title_fullStr | Impact of SARS-CoV-2 on neuropsychiatric disorders |
title_full_unstemmed | Impact of SARS-CoV-2 on neuropsychiatric disorders |
title_short | Impact of SARS-CoV-2 on neuropsychiatric disorders |
title_sort | impact of sars-cov-2 on neuropsychiatric disorders |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311516/ https://www.ncbi.nlm.nih.gov/pubmed/34327127 http://dx.doi.org/10.5498/wjp.v11.i7.347 |
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