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Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome
[Image: see text] Intracellular chloride concentration [Cl(–)](i) is defective in several neurological disorders. In neurons, [Cl(–)](i) is mainly regulated by the action of the Na(+)–K(+)–Cl(–) importer NKCC1 and the K(+)–Cl(–) exporter KCC2. Recently, we have reported the discovery of ARN23746 as...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311653/ https://www.ncbi.nlm.nih.gov/pubmed/34137257 http://dx.doi.org/10.1021/acs.jmedchem.1c00603 |