A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer

Immune channel inhibitor–induced myocarditis is rare, and its management is challenging. Recently, guidelines were established for all ICIs, yet they do not take into account individual drug toxicities or screening protocols for prevention. We present a rare case of rapidly progressive pembrolizumab...

Descripción completa

Detalles Bibliográficos
Autores principales: Cohen, Max, Mustafa, Saim, Elkherpitawy, Islam, Meleka, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Mini-Focus Issue on Heart Failure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311714/
https://www.ncbi.nlm.nih.gov/pubmed/34317255
http://dx.doi.org/10.1016/j.jaccas.2019.12.045
_version_ 1783729013937668096
author Cohen, Max
Mustafa, Saim
Elkherpitawy, Islam
Meleka, Matthew
author_facet Cohen, Max
Mustafa, Saim
Elkherpitawy, Islam
Meleka, Matthew
author_sort Cohen, Max
collection PubMed
description Immune channel inhibitor–induced myocarditis is rare, and its management is challenging. Recently, guidelines were established for all ICIs, yet they do not take into account individual drug toxicities or screening protocols for prevention. We present a rare case of rapidly progressive pembrolizumab-induced fatal myocarditis in an initially asymptomatic patient. (Level of Difficulty: Beginner.)
format Online
Article
Text
id pubmed-8311714
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83117142021-07-26 A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer Cohen, Max Mustafa, Saim Elkherpitawy, Islam Meleka, Matthew JACC Case Rep Mini-Focus Issue on Heart Failure Immune channel inhibitor–induced myocarditis is rare, and its management is challenging. Recently, guidelines were established for all ICIs, yet they do not take into account individual drug toxicities or screening protocols for prevention. We present a rare case of rapidly progressive pembrolizumab-induced fatal myocarditis in an initially asymptomatic patient. (Level of Difficulty: Beginner.) Elsevier 2020-03-18 /pmc/articles/PMC8311714/ /pubmed/34317255 http://dx.doi.org/10.1016/j.jaccas.2019.12.045 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Focus Issue on Heart Failure
Cohen, Max
Mustafa, Saim
Elkherpitawy, Islam
Meleka, Matthew
A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer
title A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer
title_full A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer
title_fullStr A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer
title_full_unstemmed A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer
title_short A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer
title_sort fatal case of pembrolizumab-induced myocarditis in non–small cell lung cancer
topic Mini-Focus Issue on Heart Failure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311714/
https://www.ncbi.nlm.nih.gov/pubmed/34317255
http://dx.doi.org/10.1016/j.jaccas.2019.12.045
work_keys_str_mv AT cohenmax afatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT mustafasaim afatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT elkherpitawyislam afatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT melekamatthew afatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT cohenmax fatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT mustafasaim fatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT elkherpitawyislam fatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer
AT melekamatthew fatalcaseofpembrolizumabinducedmyocarditisinnonsmallcelllungcancer

Ejemplares similares