Cargando…

Single‐cell transcriptomics reveals immune response of intestinal cell types to viral infection

Human intestinal epithelial cells form a primary barrier protecting us from pathogens, yet only limited knowledge is available about individual contribution of each cell type to mounting an immune response against infection. Here, we developed a framework combining single‐cell RNA‐Seq and highly mul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Triana, Sergio, Stanifer, Megan L, Metz‐Zumaran, Camila, Shahraz, Mohammed, Mukenhirn, Markus, Kee, Carmon, Serger, Clara, Koschny, Ronald, Ordoñez‐Rueda, Diana, Paulsen, Malte, Benes, Vladimir, Boulant, Steeve, Alexandrov, Theodore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311733/ https://www.ncbi.nlm.nih.gov/pubmed/34309190 http://dx.doi.org/10.15252/msb.20209833

Ejemplares similares

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells
por: Stanifer, Megan L., et al.
Publicado: (2020)

Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells
por: Metz-Zumaran, Camila, et al.
Publicado: (2022)

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut
por: Triana, Sergio, et al.
Publicado: (2021)

Type III and Not Type I Interferons Efficiently Prevent the Spread of Rotavirus in Human Intestinal Epithelial Cells
por: Doldan, Patricio, et al.
Publicado: (2022)

Extended methods for spatial cell classification with DBSCAN-CellX
por: Küchenhoff, Leonie, et al.
Publicado: (2023)

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity
por: Ramirez Alvarez, Carlos, et al.
Publicado: (2021)

Dynamics of Virus-Receptor Interactions in Virus Binding, Signaling, and Endocytosis
por: Boulant, Steeve, et al.
Publicado: (2015)

Differential Regulation of Type I and Type III Interferon Signaling
por: Stanifer, Megan L., et al.
Publicado: (2019)

Regionalization of the antiviral response in the gastrointestinal tract to provide spatially controlled host/pathogen interactions
por: Stanifer, Megan L., et al.
Publicado: (2023)

Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection
por: Tekes, Gergely, et al.
Publicado: (2020)

Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
por: Stanifer, Megan L., et al.
Publicado: (2020)

Mapping the epithelial–immune cell interactome upon infection in the gut and the upper airways
por: Poletti, Martina, et al.
Publicado: (2022)

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
por: Koch, Jana, et al.
Publicado: (2021)

Reovirus inhibits interferon production by sequestering IRF3 into viral factories
por: Stanifer, Megan L., et al.
Publicado: (2017)

Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin–Darby canine kidney cells
por: Boulant, Steeve, et al.
Publicado: (2013)

A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
por: Laise, Pasquale, et al.
Publicado: (2022)

A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
por: Laise, Pasquale, et al.
Publicado: (2022)

Role of Clathrin Light Chains in Regulating Invadopodia Formation
por: Mukenhirn, Markus, et al.
Publicado: (2021)

Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells
por: Bilz, Nicole C., et al.
Publicado: (2019)

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
por: Triana, Sergio, et al.
Publicado: (2021)

Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
por: Onabajo, Olusegun O., et al.
Publicado: (2020)

The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms
por: He, Liping, et al.
Publicado: (2022)

Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut
por: Pervolaraki, Kalliopi, et al.
Publicado: (2017)

Rubella Virus Strain-Associated Differences in the Induction of Oxidative Stress Are Independent of Their Interferon Activation
por: Zobel, Sarah, et al.
Publicado: (2018)

Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins
por: Guo, Cuncai, et al.
Publicado: (2021)

Invasiveness of Escherichia coli Is Associated with an IncFII Plasmid
por: Krall, Lars Johannes, et al.
Publicado: (2021)

SARS‐CoV‐2 infection remodels the host protein thermal stability landscape
por: Selkrig, Joel, et al.
Publicado: (2021)

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
por: Klein, Steffen, et al.
Publicado: (2020)

Silencing SOCS1 via Liposome-Packed siRNA Sustains TLR4-Ligand Adjuvant
por: Hildebrand, Dagmar, et al.
Publicado: (2019)

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells
por: Garreta, Elena, et al.
Publicado: (2022)

Increasing quantitation in spatial single-cell metabolomics by using fluorescence as ground truth
por: Molenaar, Martijn R., et al.
Publicado: (2022)

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
por: Petitjean, Simon J. L., et al.
Publicado: (2022)

Author Correction: Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
por: Petitjean, Simon J. L., et al.
Publicado: (2022)

Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
por: van Jaarsveld, Marijn T. M., et al.
Publicado: (2020)

Host Cell Nucleolin Is Required To Maintain the Architecture of Human Cytomegalovirus Replication Compartments
por: Strang, Blair L., et al.
Publicado: (2012)

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance
por: Pervolaraki, Kalliopi, et al.
Publicado: (2018)

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING
por: Karlowitz, Rebekka, et al.
Publicado: (2022)

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses
por: Fakhiri, Julia, et al.
Publicado: (2019)

Manipulating atom and photon entanglement: from 'thought experiments' to quantum information processing
por: Haroche, Serger
Publicado: (2002)

Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense
por: Boulant, Steeve, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_29fbdfjjc9s6c8fso5inqd0mp5