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Genetic Rescue of X-Linked Retinoschisis Mouse (Rs1(−/y)) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8-RS1 Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery

To understand RS1 gene interaction networks in the X-linked retinoschisis (XLRS) mouse retina (Rs1(−/y)), we analyzed the transcriptome by RNA sequencing before and after in vivo expression of exogenous retinoschisin (RS1) gene delivered by AAV8. RS1 is a secreted cell adhesion protein that is criti...

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Detalles Bibliográficos
Autores principales:	Vijayasarathy, Camasamudram, Zeng, Yong, Brooks, Matthew J., Fariss, Robert N., Sieving, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312029/ https://www.ncbi.nlm.nih.gov/pubmed/33019822 http://dx.doi.org/10.1089/hum.2020.213

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