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Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation

Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preser...

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Detalles Bibliográficos
Autores principales: Datta, Shaishav, Fitzpatrick, Aisling M, Haykal, Siba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312154/
https://www.ncbi.nlm.nih.gov/pubmed/34367640
http://dx.doi.org/10.1177/20503121211034924
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author Datta, Shaishav
Fitzpatrick, Aisling M
Haykal, Siba
author_facet Datta, Shaishav
Fitzpatrick, Aisling M
Haykal, Siba
author_sort Datta, Shaishav
collection PubMed
description Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preservation techniques when subjected to extended storage times prior to transplantation. While static cold storage functions to reduce ischemic damage and is widely employed in clinical settings, there exists no consensus on the ideal preservation solution for vascularized composite allotransplantation. This review aims to highlight current clinical and experimental advances in preservation solution development and their critical role in attenuating ischemia–reperfusion injury in the context of vascularized composite allotransplantation.
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spelling pubmed-83121542021-08-06 Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation Datta, Shaishav Fitzpatrick, Aisling M Haykal, Siba SAGE Open Med Original Research Article Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preservation techniques when subjected to extended storage times prior to transplantation. While static cold storage functions to reduce ischemic damage and is widely employed in clinical settings, there exists no consensus on the ideal preservation solution for vascularized composite allotransplantation. This review aims to highlight current clinical and experimental advances in preservation solution development and their critical role in attenuating ischemia–reperfusion injury in the context of vascularized composite allotransplantation. SAGE Publications 2021-07-21 /pmc/articles/PMC8312154/ /pubmed/34367640 http://dx.doi.org/10.1177/20503121211034924 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Datta, Shaishav
Fitzpatrick, Aisling M
Haykal, Siba
Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
title Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
title_full Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
title_fullStr Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
title_full_unstemmed Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
title_short Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
title_sort preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312154/
https://www.ncbi.nlm.nih.gov/pubmed/34367640
http://dx.doi.org/10.1177/20503121211034924
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