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Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preser...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312154/ https://www.ncbi.nlm.nih.gov/pubmed/34367640 http://dx.doi.org/10.1177/20503121211034924 |
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author | Datta, Shaishav Fitzpatrick, Aisling M Haykal, Siba |
author_facet | Datta, Shaishav Fitzpatrick, Aisling M Haykal, Siba |
author_sort | Datta, Shaishav |
collection | PubMed |
description | Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preservation techniques when subjected to extended storage times prior to transplantation. While static cold storage functions to reduce ischemic damage and is widely employed in clinical settings, there exists no consensus on the ideal preservation solution for vascularized composite allotransplantation. This review aims to highlight current clinical and experimental advances in preservation solution development and their critical role in attenuating ischemia–reperfusion injury in the context of vascularized composite allotransplantation. |
format | Online Article Text |
id | pubmed-8312154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-83121542021-08-06 Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation Datta, Shaishav Fitzpatrick, Aisling M Haykal, Siba SAGE Open Med Original Research Article Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preservation techniques when subjected to extended storage times prior to transplantation. While static cold storage functions to reduce ischemic damage and is widely employed in clinical settings, there exists no consensus on the ideal preservation solution for vascularized composite allotransplantation. This review aims to highlight current clinical and experimental advances in preservation solution development and their critical role in attenuating ischemia–reperfusion injury in the context of vascularized composite allotransplantation. SAGE Publications 2021-07-21 /pmc/articles/PMC8312154/ /pubmed/34367640 http://dx.doi.org/10.1177/20503121211034924 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Datta, Shaishav Fitzpatrick, Aisling M Haykal, Siba Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
title | Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
title_full | Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
title_fullStr | Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
title_full_unstemmed | Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
title_short | Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
title_sort | preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312154/ https://www.ncbi.nlm.nih.gov/pubmed/34367640 http://dx.doi.org/10.1177/20503121211034924 |
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