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Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes

In humans, taste genes are responsible for perceiving at least 5 different taste qualities. Human taste genes’ evolutionary mechanisms need to be explored. We compiled a list of 69 human taste-related genes and divided them into 7 functional groups. We carried out comparative genomic and evolutionar...

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Detalles Bibliográficos
Autores principales: Wang, Yupeng, Sun, Ying, Joseph, Paule Valery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312168/
https://www.ncbi.nlm.nih.gov/pubmed/34366662
http://dx.doi.org/10.1177/11769343211035141
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author Wang, Yupeng
Sun, Ying
Joseph, Paule Valery
author_facet Wang, Yupeng
Sun, Ying
Joseph, Paule Valery
author_sort Wang, Yupeng
collection PubMed
description In humans, taste genes are responsible for perceiving at least 5 different taste qualities. Human taste genes’ evolutionary mechanisms need to be explored. We compiled a list of 69 human taste-related genes and divided them into 7 functional groups. We carried out comparative genomic and evolutionary analyses for these taste genes based on 8 vertebrate species. We found that relative to other groups of human taste genes, human TAS2R genes have a higher proportion of tandem duplicates, suggesting that tandem duplications have contributed significantly to the expansion of the human TAS2R gene family. Human TAS2R genes tend to have fewer collinear genes in outgroup species and evolve faster, suggesting that human TAS2R genes have experienced more gene relocations. Moreover, human TAS2R genes tend to be under more relaxed purifying selection than other genes. Our study sheds new insights into diverse and contrasting evolutionary patterns among human taste genes.
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spelling pubmed-83121682021-08-06 Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes Wang, Yupeng Sun, Ying Joseph, Paule Valery Evol Bioinform Online Original Research In humans, taste genes are responsible for perceiving at least 5 different taste qualities. Human taste genes’ evolutionary mechanisms need to be explored. We compiled a list of 69 human taste-related genes and divided them into 7 functional groups. We carried out comparative genomic and evolutionary analyses for these taste genes based on 8 vertebrate species. We found that relative to other groups of human taste genes, human TAS2R genes have a higher proportion of tandem duplicates, suggesting that tandem duplications have contributed significantly to the expansion of the human TAS2R gene family. Human TAS2R genes tend to have fewer collinear genes in outgroup species and evolve faster, suggesting that human TAS2R genes have experienced more gene relocations. Moreover, human TAS2R genes tend to be under more relaxed purifying selection than other genes. Our study sheds new insights into diverse and contrasting evolutionary patterns among human taste genes. SAGE Publications 2021-07-24 /pmc/articles/PMC8312168/ /pubmed/34366662 http://dx.doi.org/10.1177/11769343211035141 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Wang, Yupeng
Sun, Ying
Joseph, Paule Valery
Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes
title Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes
title_full Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes
title_fullStr Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes
title_full_unstemmed Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes
title_short Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes
title_sort contrasting patterns of gene duplication, relocation, and selection among human taste genes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312168/
https://www.ncbi.nlm.nih.gov/pubmed/34366662
http://dx.doi.org/10.1177/11769343211035141
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