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MUSTARD—a comprehensive resource of mutation-specific therapies in cancer
The steady increase in global cancer burden has fuelled the development of several modes of treatment for the disease. In the presence of an actionable mutation, targeted therapies offer a method to selectively attack cancer cells, increasing overall efficacy and reducing harmful side effects. Howev...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312254/ https://www.ncbi.nlm.nih.gov/pubmed/34309639 http://dx.doi.org/10.1093/database/baab042 |
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author | Mittal, Gauri R I, Anu Vatsyayan, Aastha Pandhare, Kavita Scaria, Vinod |
author_facet | Mittal, Gauri R I, Anu Vatsyayan, Aastha Pandhare, Kavita Scaria, Vinod |
author_sort | Mittal, Gauri |
collection | PubMed |
description | The steady increase in global cancer burden has fuelled the development of several modes of treatment for the disease. In the presence of an actionable mutation, targeted therapies offer a method to selectively attack cancer cells, increasing overall efficacy and reducing harmful side effects. However, different drug molecules are in different stages of development, with new molecules obtaining approvals from regulatory agencies each year. To augment clinical impact, it is important that this information reaches clinicians, patients and researchers swiftly and in a structured, well-annotated manner. To this end, we have developed Mutation-Specific Therapies Resource and Database in Cancer (MUSTARD), a database that is designed to be a centralized resource with diverse information such as cancer subtype, associated mutations, therapy offered and its effect observed, along with links to external resources for a more comprehensive annotation. In its current version, MUSTARD comprises over 2105 unique entries, including associations between 418 unique drug therapies, 189 cancer subtypes and 167 genes curated and annotated from over 862 different publications. To the best of our knowledge, it is the only resource that offers comprehensive information on mutation-specific, gene fusions and overexpressed gene-targeted therapies for cancer. Database URL: http://clingen.igib.res.in/mustard/ |
format | Online Article Text |
id | pubmed-8312254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-83122542021-07-27 MUSTARD—a comprehensive resource of mutation-specific therapies in cancer Mittal, Gauri R I, Anu Vatsyayan, Aastha Pandhare, Kavita Scaria, Vinod Database (Oxford) Original Article The steady increase in global cancer burden has fuelled the development of several modes of treatment for the disease. In the presence of an actionable mutation, targeted therapies offer a method to selectively attack cancer cells, increasing overall efficacy and reducing harmful side effects. However, different drug molecules are in different stages of development, with new molecules obtaining approvals from regulatory agencies each year. To augment clinical impact, it is important that this information reaches clinicians, patients and researchers swiftly and in a structured, well-annotated manner. To this end, we have developed Mutation-Specific Therapies Resource and Database in Cancer (MUSTARD), a database that is designed to be a centralized resource with diverse information such as cancer subtype, associated mutations, therapy offered and its effect observed, along with links to external resources for a more comprehensive annotation. In its current version, MUSTARD comprises over 2105 unique entries, including associations between 418 unique drug therapies, 189 cancer subtypes and 167 genes curated and annotated from over 862 different publications. To the best of our knowledge, it is the only resource that offers comprehensive information on mutation-specific, gene fusions and overexpressed gene-targeted therapies for cancer. Database URL: http://clingen.igib.res.in/mustard/ Oxford University Press 2021-07-26 /pmc/articles/PMC8312254/ /pubmed/34309639 http://dx.doi.org/10.1093/database/baab042 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mittal, Gauri R I, Anu Vatsyayan, Aastha Pandhare, Kavita Scaria, Vinod MUSTARD—a comprehensive resource of mutation-specific therapies in cancer |
title | MUSTARD—a comprehensive resource of mutation-specific therapies in cancer |
title_full | MUSTARD—a comprehensive resource of mutation-specific therapies in cancer |
title_fullStr | MUSTARD—a comprehensive resource of mutation-specific therapies in cancer |
title_full_unstemmed | MUSTARD—a comprehensive resource of mutation-specific therapies in cancer |
title_short | MUSTARD—a comprehensive resource of mutation-specific therapies in cancer |
title_sort | mustard—a comprehensive resource of mutation-specific therapies in cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312254/ https://www.ncbi.nlm.nih.gov/pubmed/34309639 http://dx.doi.org/10.1093/database/baab042 |
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