Cargando…
Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atheros...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312325/ https://www.ncbi.nlm.nih.gov/pubmed/34322373 http://dx.doi.org/10.2147/PTT.S320016 |
_version_ | 1783729126212894720 |
---|---|
author | Teklu, Meron Parel, Philip M Mehta, Nehal N |
author_facet | Teklu, Meron Parel, Philip M Mehta, Nehal N |
author_sort | Teklu, Meron |
collection | PubMed |
description | Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. In this review, we discuss the role of inflammation and psoriasis in cardiometabolic diseases with a focus on the metabolic syndrome and its components. We highlight the relationship between psoriasis and important cardiovascular risk factors encompassed by obesity, dyslipidemia, insulin resistance and hypertension. Furthermore, we briefly highlight literature on anti-inflammatory therapies and their impact on the components of the metabolic syndrome as well as directly quantified coronary atherosclerosis burden. |
format | Online Article Text |
id | pubmed-8312325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-83123252021-07-27 Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health Teklu, Meron Parel, Philip M Mehta, Nehal N Psoriasis (Auckl) Review Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. In this review, we discuss the role of inflammation and psoriasis in cardiometabolic diseases with a focus on the metabolic syndrome and its components. We highlight the relationship between psoriasis and important cardiovascular risk factors encompassed by obesity, dyslipidemia, insulin resistance and hypertension. Furthermore, we briefly highlight literature on anti-inflammatory therapies and their impact on the components of the metabolic syndrome as well as directly quantified coronary atherosclerosis burden. Dove 2021-07-21 /pmc/articles/PMC8312325/ /pubmed/34322373 http://dx.doi.org/10.2147/PTT.S320016 Text en © 2021 Teklu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Teklu, Meron Parel, Philip M Mehta, Nehal N Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health |
title | Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health |
title_full | Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health |
title_fullStr | Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health |
title_full_unstemmed | Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health |
title_short | Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health |
title_sort | psoriasis and cardiometabolic diseases: the impact of inflammation on vascular health |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312325/ https://www.ncbi.nlm.nih.gov/pubmed/34322373 http://dx.doi.org/10.2147/PTT.S320016 |
work_keys_str_mv | AT teklumeron psoriasisandcardiometabolicdiseasestheimpactofinflammationonvascularhealth AT parelphilipm psoriasisandcardiometabolicdiseasestheimpactofinflammationonvascularhealth AT mehtanehaln psoriasisandcardiometabolicdiseasestheimpactofinflammationonvascularhealth |