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Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect

Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers. We studied and compared the in vitro, in vivo, and in silico effects of some crambescine A and C analogs. HepG2 gene expression was analyz...

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Detalles Bibliográficos
Autores principales:	Rubiolo, Juan A., Lence, Emilio, González-Bello, Concepción, Roel, María, Gil-Longo, José, Campos-Toimil, Manuel, Ternon, Eva, Thomas, Olivier P., González-Cantalapiedra, Antonio, López-Alonso, Henar, Vieytes, Mercedes R., Botana, Luis M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312399/ https://www.ncbi.nlm.nih.gov/pubmed/34322022 http://dx.doi.org/10.3389/fphar.2021.694639

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