Cargando…

A high-content platform for physiological profiling and unbiased classification of individual neurons

High-throughput physiological assays lose single-cell resolution, precluding subtype-specific analyses of activation mechanism and drug effects. We demonstrate APPOINT (automated physiological phenotyping of individual neuronal types), a physiological assay platform combining calcium imaging, roboti...

Descripción completa

Detalles Bibliográficos
Autores principales:	DuBreuil, Daniel M., Chiang, Brenda M., Zhu, Kevin, Lai, Xiaofan, Flynn, Patrick, Sapir, Yechiam, Wainger, Brian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312640/ https://www.ncbi.nlm.nih.gov/pubmed/34318289 http://dx.doi.org/10.1016/j.crmeth.2021.100004

Ejemplares similares

Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
por: Pereira, João D., et al.
Publicado: (2021)

Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic
por: DuBreuil, Daniel M, et al.
Publicado: (2023)

Pharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons
por: Moakley, Daniel, et al.
Publicado: (2019)

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging
por: Severo, Maiara S., et al.
Publicado: (2018)

Fluopack screening platform for unbiased cellular phenotype profiling
por: Kang, Zhao B., et al.
Publicado: (2020)

Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated Ca(V)2.2 Calcium Channel Activity in Peripheral Axon Terminals Innervating Skin
por: DuBreuil, Daniel M., et al.
Publicado: (2021)

Anatomy and physiology of peer review process, can it be unbiased?
por: Kumar, Arun H. S.
Publicado: (2014)

Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration
por: Golub, Victoria M., et al.
Publicado: (2015)

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans
por: Clark, Andrew S., et al.
Publicado: (2023)

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans
por: Clark, Andrew S., et al.
Publicado: (2023)

Interneuron diversity in the rat dentate gyrus: An unbiased in vitro classification
por: Degro, Claudius E., et al.
Publicado: (2022)

Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines
por: Risher, W. Christopher, et al.
Publicado: (2014)

An Automated Strategy for Unbiased Morphometric Analyses and Classifications of Growth Cones In Vitro
por: Chitsaz, Daryan, et al.
Publicado: (2015)

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers
por: Jack, Clifford R., et al.
Publicado: (2016)

An Unbiased Estimator of Gene Diversity in Samples Containing Related Individuals
por: DeGiorgio, Michael, et al.
Publicado: (2009)

Unbiased estimators and their applications
por: Voinov, V G, et al.
Publicado: (1993)

Urine stabilization and normalization strategies favor unbiased analysis of urinary EV content
por: Vago, Riccardo, et al.
Publicado: (2022)

Hands-On Music Generation with Magenta
por: DuBreuil, Alexandre
Publicado: (2020)

An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery
por: Mohammed, Zainab A., et al.
Publicado: (2020)

A High Throughput and Unbiased Machine Learning Approach for Classification of Graphene Dispersions
por: Abedin, Md. Joynul, et al.
Publicado: (2020)

Unbiased pangenome graphs
por: Garrison, Erik, et al.
Publicado: (2022)

Towards a Rapid-Turnaround Low-Depth Unbiased Metagenomics Sequencing Workflow on the Illumina Platforms
por: Koh, Winston Lian Chye, et al.
Publicado: (2023)

Unbiased stereology : three-dimensional measurement in microscopy /
por: Howard, Vyvyan
Publicado: (1998)

Unique Internet Search Strategies of Individuals With Self-Stated Autism: Quantitative Analysis of Search Engine Users’ Investigative Behaviors
por: Yechiam, Eldad, et al.
Publicado: (2021)

Ten simple rules for unbiased teaching
por: Mobbs, Dean, et al.
Publicado: (2022)

Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas
por: Kukutla, Phanidhar, et al.
Publicado: (2021)

Efficient and Unbiased Estimation of Population Size
por: Cruz, Marcos, et al.
Publicado: (2015)

Transforming bioengineering with unbiased teams and tools
por: Jewell, Christopher M., et al.
Publicado: (2023)

Towards an unbiased view of science
Publicado: (2015)

Properties and unbiased estimation of F- and D-statistics in samples containing related and inbred individuals
por: Mughal, Mehreen R, et al.
Publicado: (2021)

Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop-the-losers trials
por: Bowden, Jack, et al.
Publicado: (2014)

An Unbiased Estimator of Gene Diversity with Improved Variance for Samples Containing Related and Inbred Individuals of any Ploidy
por: Harris, Alexandre M., et al.
Publicado: (2016)

Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult
por: Li, Qi, et al.
Publicado: (2013)

A platform for brain-wide imaging and reconstruction of individual neurons
por: Economo, Michael N, et al.
Publicado: (2016)

Unbiased integration of single cell transcriptome replicates
por: Loza, Martin, et al.
Publicado: (2022)

Erratum to: Properties and unbiased estimation of F- and D-statistics in samples containing related and inbred individuals
Publicado: (2021)

A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data
por: Momin, Md. Moksedul, et al.
Publicado: (2023)

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts
por: Schiff, Lauren, et al.
Publicado: (2022)

Unbiased estimation of the breeding value of bulls
por: Osterkorn, K
Publicado: (1976)

Optimal unbiased estimation of variance components
por: Malley, James D
Publicado: (1986)

Cannot write session to /tmp/vufind_sessions/sess_kt8k7m7fkrgrqovq4u1cgqmal7