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Efficient interspecies transmission of synthetic prions

Prions are comprised solely of PrP(Sc), the misfolded self-propagating conformation of the cellular protein, PrP(C). Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals. It is unknown, however, if synthetic prions can cross the species barrier...

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Detalles Bibliográficos
Autores principales:	Block, Alyssa J., Shikiya, Ronald A., Eckland, Thomas E., Kincaid, Anthony E., Walters, Ryan W., Ma, Jiyan, Bartz, Jason C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312972/ https://www.ncbi.nlm.nih.gov/pubmed/34260664 http://dx.doi.org/10.1371/journal.ppat.1009765

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