Unified platform for genetic and serological detection of COVID-19 with single-molecule technology

Mostrar otras versiones (1)

The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for...

Descripción completa

Detalles Bibliográficos
Autores principales: Furth, Noa, Shilo, Shay, Cohen, Niv, Erez, Nir, Fedyuk, Vadim, Schrager, Alexander M., Weinberger, Adina, Dror, Amiel A., Zigron, Asaf, Shehadeh, Mona, Sela, Eyal, Srouji, Samer, Amit, Sharon, Levy, Itzchak, Segal, Eran, Dahan, Rony, Jones, Dan, Douek, Daniel C., Shema, Efrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312974/
https://www.ncbi.nlm.nih.gov/pubmed/34310620
http://dx.doi.org/10.1371/journal.pone.0255096
Descripción
Sumario:The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients’ samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens.

Ejemplares similares