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Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely available drugs with anti‐inflammatory and analgesic properties. Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX‐1 and COX‐2). The cyclooxygenase pathway results in the formation of...

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Autores principales: Drożdżal, Sylwester, Lechowicz, Kacper, Szostak, Bartosz, Rosik, Jakub, Kotfis, Katarzyna, Machoy‐Mokrzyńska, Anna, Białecka, Monika, Ciechanowski, Kazimierz, Gawrońska‐Szklarz, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313037/
https://www.ncbi.nlm.nih.gov/pubmed/34310861
http://dx.doi.org/10.1002/prp2.817
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author Drożdżal, Sylwester
Lechowicz, Kacper
Szostak, Bartosz
Rosik, Jakub
Kotfis, Katarzyna
Machoy‐Mokrzyńska, Anna
Białecka, Monika
Ciechanowski, Kazimierz
Gawrońska‐Szklarz, Barbara
author_facet Drożdżal, Sylwester
Lechowicz, Kacper
Szostak, Bartosz
Rosik, Jakub
Kotfis, Katarzyna
Machoy‐Mokrzyńska, Anna
Białecka, Monika
Ciechanowski, Kazimierz
Gawrońska‐Szklarz, Barbara
author_sort Drożdżal, Sylwester
collection PubMed
description Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely available drugs with anti‐inflammatory and analgesic properties. Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX‐1 and COX‐2). The cyclooxygenase pathway results in the formation of prostanoids (prostaglandins [PGs], prostacyclins, and thromboxanes). It affects various structures of the human body, including the kidneys. Medical literature associates the usage of NSAIDs with acute kidney injury (AKI), tubulointerstitial nephritis (TIN), as well as nephrotic syndrome and chronic kidney disease (CKD). AKI associated with the chronic consumption of NSAIDs is mainly attributed to pharmacological polytherapy and the presence of cardiovascular or hepatic comorbidities. The pathomechanism of AKI and CKD is associated with inhibition of the biosynthesis of prostanoids involved in the maintenance of renal blood flow, especially PGE2 and PGI2. It is suggested that both COX isoforms play opposing roles in renal function, with natriuresis increased by COX‐1 inhibition followed by a drop in a blood pressure, whereas COX‐2 inhibition increases blood pressure and promotes sodium retention. TIN after NSAID use is potentially associated with glomerular basement membrane damage, reduction in pore size, and podocyte density. Therefore, nephrotic proteinuria and impairment of renal function may occur. The following article analyzes the association of NSAIDs with kidney disease based on available medical literature.
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spelling pubmed-83130372021-07-30 Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature Drożdżal, Sylwester Lechowicz, Kacper Szostak, Bartosz Rosik, Jakub Kotfis, Katarzyna Machoy‐Mokrzyńska, Anna Białecka, Monika Ciechanowski, Kazimierz Gawrońska‐Szklarz, Barbara Pharmacol Res Perspect Reviews Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely available drugs with anti‐inflammatory and analgesic properties. Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX‐1 and COX‐2). The cyclooxygenase pathway results in the formation of prostanoids (prostaglandins [PGs], prostacyclins, and thromboxanes). It affects various structures of the human body, including the kidneys. Medical literature associates the usage of NSAIDs with acute kidney injury (AKI), tubulointerstitial nephritis (TIN), as well as nephrotic syndrome and chronic kidney disease (CKD). AKI associated with the chronic consumption of NSAIDs is mainly attributed to pharmacological polytherapy and the presence of cardiovascular or hepatic comorbidities. The pathomechanism of AKI and CKD is associated with inhibition of the biosynthesis of prostanoids involved in the maintenance of renal blood flow, especially PGE2 and PGI2. It is suggested that both COX isoforms play opposing roles in renal function, with natriuresis increased by COX‐1 inhibition followed by a drop in a blood pressure, whereas COX‐2 inhibition increases blood pressure and promotes sodium retention. TIN after NSAID use is potentially associated with glomerular basement membrane damage, reduction in pore size, and podocyte density. Therefore, nephrotic proteinuria and impairment of renal function may occur. The following article analyzes the association of NSAIDs with kidney disease based on available medical literature. John Wiley and Sons Inc. 2021-07-26 /pmc/articles/PMC8313037/ /pubmed/34310861 http://dx.doi.org/10.1002/prp2.817 Text en © 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Drożdżal, Sylwester
Lechowicz, Kacper
Szostak, Bartosz
Rosik, Jakub
Kotfis, Katarzyna
Machoy‐Mokrzyńska, Anna
Białecka, Monika
Ciechanowski, Kazimierz
Gawrońska‐Szklarz, Barbara
Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature
title Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature
title_full Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature
title_fullStr Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature
title_full_unstemmed Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature
title_short Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature
title_sort kidney damage from nonsteroidal anti‐inflammatory drugs—myth or truth? review of selected literature
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313037/
https://www.ncbi.nlm.nih.gov/pubmed/34310861
http://dx.doi.org/10.1002/prp2.817
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