Antiarrhythmic Drugs for Atrial Fibrillation: Selected Features of Ventricular Repolarization That Facilitate Proarrhythmic Torsades de Pointes and Favor Inpatient Initiation

The management approaches to patients with atrial fibrillation (AF) include rhythm-control strategies for those patients who are symptomatic despite rate control and for selected others in whom sinus rhythm is necessary for reasons beyond current symptoms (including commercial pilots, those who are felt likely to develop symptoms as comorbidities progress, and more). First-line therapies among the rhythm-control options are antiarrhythmic drugs (AADs). For many AADs, their initiation in-hospital is either a requirement or strongly advised— especially when the patient is in AF. This article explores some of the rationale behind this requirement to give clinicians a better understanding of the reasons for this undesired inconvenience.