Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds

The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current r...

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Detalles Bibliográficos
Autores principales: Khezri, Khadijeh, Maleki Dizaj, Solmaz, Rahbar Saadat, Yalda, Sharifi, Simin, Shahi, Shahriar, Ahmadian, Elham, Eftekhari, Aziz, Dalir Abdolahinia, Elaheh, Lotfipour, Farzaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313343/
https://www.ncbi.nlm.nih.gov/pubmed/34335789
http://dx.doi.org/10.1155/2021/1520052
Descripción
Sumario:The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.

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