Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds

The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current r...

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Autores principales: Khezri, Khadijeh, Maleki Dizaj, Solmaz, Rahbar Saadat, Yalda, Sharifi, Simin, Shahi, Shahriar, Ahmadian, Elham, Eftekhari, Aziz, Dalir Abdolahinia, Elaheh, Lotfipour, Farzaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313343/
https://www.ncbi.nlm.nih.gov/pubmed/34335789
http://dx.doi.org/10.1155/2021/1520052
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author Khezri, Khadijeh
Maleki Dizaj, Solmaz
Rahbar Saadat, Yalda
Sharifi, Simin
Shahi, Shahriar
Ahmadian, Elham
Eftekhari, Aziz
Dalir Abdolahinia, Elaheh
Lotfipour, Farzaneh
author_facet Khezri, Khadijeh
Maleki Dizaj, Solmaz
Rahbar Saadat, Yalda
Sharifi, Simin
Shahi, Shahriar
Ahmadian, Elham
Eftekhari, Aziz
Dalir Abdolahinia, Elaheh
Lotfipour, Farzaneh
author_sort Khezri, Khadijeh
collection PubMed
description The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.
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spelling pubmed-83133432021-07-31 Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds Khezri, Khadijeh Maleki Dizaj, Solmaz Rahbar Saadat, Yalda Sharifi, Simin Shahi, Shahriar Ahmadian, Elham Eftekhari, Aziz Dalir Abdolahinia, Elaheh Lotfipour, Farzaneh Stem Cells Int Review Article The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed. Hindawi 2021-07-17 /pmc/articles/PMC8313343/ /pubmed/34335789 http://dx.doi.org/10.1155/2021/1520052 Text en Copyright © 2021 Khadijeh Khezri et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khezri, Khadijeh
Maleki Dizaj, Solmaz
Rahbar Saadat, Yalda
Sharifi, Simin
Shahi, Shahriar
Ahmadian, Elham
Eftekhari, Aziz
Dalir Abdolahinia, Elaheh
Lotfipour, Farzaneh
Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
title Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
title_full Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
title_fullStr Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
title_full_unstemmed Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
title_short Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
title_sort osteogenic differentiation of mesenchymal stem cells via curcumin-containing nanoscaffolds
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313343/
https://www.ncbi.nlm.nih.gov/pubmed/34335789
http://dx.doi.org/10.1155/2021/1520052
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