ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses

Cytosolic double-stranded RNA (dsRNA) initiates type I IFN responses. Endogenous retroelements, notably Alu elements, constitute a source of dsRNA. Adenosine-to-inosine (A-to-I) editing by ADAR induces mismatches in dsRNA and prevents recognition by MDA5 and autoinflammation. To identify additional...

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Detalles Bibliográficos
Autores principales: Herzner, Anna-Maria, Khan, Zia, Van Nostrand, Eric L., Chan, Sara, Cuellar, Trinna, Chen, Ronald, Pechuan-Jorge, Ximo, Komuves, Laszlo, Solon, Margaret, Modrusan, Zora, Haley, Benjamin, Yeo, Gene W., Behrens, Timothy W., Albert, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313407/
https://www.ncbi.nlm.nih.gov/pubmed/34297039
http://dx.doi.org/10.1084/jem.20201833

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