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Epigenetic and transcriptional control of interferon-β

The three classes of interferons (IFNs) share the ability to inhibit viral replication, activating cell transcriptional programs that regulate both innate and adaptive responses to viral and intracellular bacterial challenge. Due to their unique potency in regulating viral replication, and their ass...

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Detalles Bibliográficos
Autores principales: Daman, Andrew W., Josefowicz, Steven Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313408/
https://www.ncbi.nlm.nih.gov/pubmed/34297037
http://dx.doi.org/10.1084/jem.20210039
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author Daman, Andrew W.
Josefowicz, Steven Z.
author_facet Daman, Andrew W.
Josefowicz, Steven Z.
author_sort Daman, Andrew W.
collection PubMed
description The three classes of interferons (IFNs) share the ability to inhibit viral replication, activating cell transcriptional programs that regulate both innate and adaptive responses to viral and intracellular bacterial challenge. Due to their unique potency in regulating viral replication, and their association with numerous autoimmune diseases, the tightly orchestrated transcriptional regulation of IFNs has long been a subject of intense investigation. The protective role of early robust IFN responses in the context of infection with SARS-CoV-2 has further underscored the relevance of these pathways. In this viewpoint, rather than focusing on the downstream effects of IFN signaling (which have been extensively reviewed elsewhere), we will summarize the historical and current understanding of the stepwise assembly and function of factors that regulate IFNβ enhancer activity (the “enhanceosome”) and highlight opportunities for deeper understanding of the transcriptional control of the ifnb gene.
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spelling pubmed-83134082022-03-06 Epigenetic and transcriptional control of interferon-β Daman, Andrew W. Josefowicz, Steven Z. J Exp Med Viewpoint The three classes of interferons (IFNs) share the ability to inhibit viral replication, activating cell transcriptional programs that regulate both innate and adaptive responses to viral and intracellular bacterial challenge. Due to their unique potency in regulating viral replication, and their association with numerous autoimmune diseases, the tightly orchestrated transcriptional regulation of IFNs has long been a subject of intense investigation. The protective role of early robust IFN responses in the context of infection with SARS-CoV-2 has further underscored the relevance of these pathways. In this viewpoint, rather than focusing on the downstream effects of IFN signaling (which have been extensively reviewed elsewhere), we will summarize the historical and current understanding of the stepwise assembly and function of factors that regulate IFNβ enhancer activity (the “enhanceosome”) and highlight opportunities for deeper understanding of the transcriptional control of the ifnb gene. Rockefeller University Press 2021-07-23 /pmc/articles/PMC8313408/ /pubmed/34297037 http://dx.doi.org/10.1084/jem.20210039 Text en © 2021 Daman and Josefowicz http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Daman, Andrew W.
Josefowicz, Steven Z.
Epigenetic and transcriptional control of interferon-β
title Epigenetic and transcriptional control of interferon-β
title_full Epigenetic and transcriptional control of interferon-β
title_fullStr Epigenetic and transcriptional control of interferon-β
title_full_unstemmed Epigenetic and transcriptional control of interferon-β
title_short Epigenetic and transcriptional control of interferon-β
title_sort epigenetic and transcriptional control of interferon-β
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313408/
https://www.ncbi.nlm.nih.gov/pubmed/34297037
http://dx.doi.org/10.1084/jem.20210039
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