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Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis
Resorcylic acid lactones (RALs) with a cis-enone moiety, represented by hypothemycin (1) and (5Z)-7-oxozeaenol (2), are fungal secondary metabolites with irreversible inhibitory activity against protein kinases, with particularly selective activity for inhibition of TAK1 (transforming growth factor...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313427/ https://www.ncbi.nlm.nih.gov/pubmed/34155352 http://dx.doi.org/10.1038/s41429-021-00432-3 |