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Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study
PURPOSE: To integrate dose-averaged linear energy transfer (LET(d)) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits. METHODS: An open-source proton planning platform (OpenREGGUI) has been modified to incorporate LET(d) into op...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313436/ https://www.ncbi.nlm.nih.gov/pubmed/34327139 http://dx.doi.org/10.3389/fonc.2021.698537 |
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author | Li, Xiaoqiang Ding, Xuanfeng Zheng, Weili Liu, Gang Janssens, Guillaume Souris, Kevin Barragán-Montero, Ana M. Yan, Di Stevens, Craig Kabolizadeh, Peyman |
author_facet | Li, Xiaoqiang Ding, Xuanfeng Zheng, Weili Liu, Gang Janssens, Guillaume Souris, Kevin Barragán-Montero, Ana M. Yan, Di Stevens, Craig Kabolizadeh, Peyman |
author_sort | Li, Xiaoqiang |
collection | PubMed |
description | PURPOSE: To integrate dose-averaged linear energy transfer (LET(d)) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits. METHODS: An open-source proton planning platform (OpenREGGUI) has been modified to incorporate LET(d) into optimization for both SPArc and multi-beam intensity-modulated proton therapy (IMPT) treatment planning. SPArc and multi-beam IMPT plans with different beam configurations for a prostate patient were generated to investigate the feasibility of LET(d)-based optimization using SPArc in terms of spatial LET(d) distribution and plan delivery efficiency. One liver and one brain case were studied to further evaluate the advantages of SPArc over multi-beam IMPT. RESULTS: With similar dose distributions, the efficacy of spatially optimizing LET(d) distributions improves with increasing number of beams. Compared with multi-beam IMPT plans, SPArc plans show substantial improvement in LET(d) distributions while maintaining similar delivery efficiency. Specifically, for the liver case, the average LET(d) in the GTV was increased by 124% for the SPArc plan, and only 9.6% for the 2-beam IMPT plan compared with the 2-beam non-LET(d) optimized IMPT plan. In case of LET optimization for the brain case, the SPArc plan could effectively increase the average LET(d) in the CTV and decrease the values in the critical structures while smaller improvement was observed in 3-beam IMPT plans. CONCLUSION: This work demonstrates the feasibility and significant advantages of using SPArc for LET(d)-based optimization, which could maximize the LET(d) distribution wherever is desired inside the target and averts the high LET(d) away from the adjacent critical organs-at-risk. |
format | Online Article Text |
id | pubmed-8313436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83134362021-07-28 Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study Li, Xiaoqiang Ding, Xuanfeng Zheng, Weili Liu, Gang Janssens, Guillaume Souris, Kevin Barragán-Montero, Ana M. Yan, Di Stevens, Craig Kabolizadeh, Peyman Front Oncol Oncology PURPOSE: To integrate dose-averaged linear energy transfer (LET(d)) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits. METHODS: An open-source proton planning platform (OpenREGGUI) has been modified to incorporate LET(d) into optimization for both SPArc and multi-beam intensity-modulated proton therapy (IMPT) treatment planning. SPArc and multi-beam IMPT plans with different beam configurations for a prostate patient were generated to investigate the feasibility of LET(d)-based optimization using SPArc in terms of spatial LET(d) distribution and plan delivery efficiency. One liver and one brain case were studied to further evaluate the advantages of SPArc over multi-beam IMPT. RESULTS: With similar dose distributions, the efficacy of spatially optimizing LET(d) distributions improves with increasing number of beams. Compared with multi-beam IMPT plans, SPArc plans show substantial improvement in LET(d) distributions while maintaining similar delivery efficiency. Specifically, for the liver case, the average LET(d) in the GTV was increased by 124% for the SPArc plan, and only 9.6% for the 2-beam IMPT plan compared with the 2-beam non-LET(d) optimized IMPT plan. In case of LET optimization for the brain case, the SPArc plan could effectively increase the average LET(d) in the CTV and decrease the values in the critical structures while smaller improvement was observed in 3-beam IMPT plans. CONCLUSION: This work demonstrates the feasibility and significant advantages of using SPArc for LET(d)-based optimization, which could maximize the LET(d) distribution wherever is desired inside the target and averts the high LET(d) away from the adjacent critical organs-at-risk. Frontiers Media S.A. 2021-07-12 /pmc/articles/PMC8313436/ /pubmed/34327139 http://dx.doi.org/10.3389/fonc.2021.698537 Text en Copyright © 2021 Li, Ding, Zheng, Liu, Janssens, Souris, Barragán-Montero, Yan, Stevens and Kabolizadeh https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Xiaoqiang Ding, Xuanfeng Zheng, Weili Liu, Gang Janssens, Guillaume Souris, Kevin Barragán-Montero, Ana M. Yan, Di Stevens, Craig Kabolizadeh, Peyman Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study |
title | Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study |
title_full | Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study |
title_fullStr | Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study |
title_full_unstemmed | Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study |
title_short | Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study |
title_sort | linear energy transfer incorporated spot-scanning proton arc therapy optimization: a feasibility study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313436/ https://www.ncbi.nlm.nih.gov/pubmed/34327139 http://dx.doi.org/10.3389/fonc.2021.698537 |
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