Cargando…

Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles

Chloro(triethylphosphine)gold(I), (Et(3)PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties. Like AF, Et(3)PAuCl exhibits potent antiproliferative properties in vitro toward a variety of cancer cell lines and is a promising anticance...

Descripción completa

Detalles Bibliográficos
Autores principales: Menconi, Alessio, Marzo, Tiziano, Massai, Lara, Pratesi, Alessandro, Severi, Mirko, Petroni, Giulia, Antonuzzo, Lorenzo, Messori, Luigi, Pillozzi, Serena, Cirri, Damiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313464/
https://www.ncbi.nlm.nih.gov/pubmed/33907910
http://dx.doi.org/10.1007/s10534-021-00313-0
_version_ 1783729354402955264
author Menconi, Alessio
Marzo, Tiziano
Massai, Lara
Pratesi, Alessandro
Severi, Mirko
Petroni, Giulia
Antonuzzo, Lorenzo
Messori, Luigi
Pillozzi, Serena
Cirri, Damiano
author_facet Menconi, Alessio
Marzo, Tiziano
Massai, Lara
Pratesi, Alessandro
Severi, Mirko
Petroni, Giulia
Antonuzzo, Lorenzo
Messori, Luigi
Pillozzi, Serena
Cirri, Damiano
author_sort Menconi, Alessio
collection PubMed
description Chloro(triethylphosphine)gold(I), (Et(3)PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties. Like AF, Et(3)PAuCl exhibits potent antiproliferative properties in vitro toward a variety of cancer cell lines and is a promising anticancer drug candidate. We wondered whether Et(3)PAuCl encapsulation might lead to an improved pharmacological profile also considering the likely reduction of unwanted side-reactions that are responsible for adverse effects and for drug inactivation. Et(3)PAuCl was encapsulated in biocompatible PLGA–PEG nanoparticles (NPs) and the new formulation evaluated in colorectal HCT-116 cancer cells in comparison to the free gold complex. Notably, encapsulated Et(3)PAuCl (nano-Et(3)PAuCl hereafter) mostly retains the cellular properties of the free gold complex and elicits even greater cytotoxic effects in colorectal cancer (CRC) cells, mediated by apoptosis and autophagy. Moreover, a remarkable inhibition of two crucial signaling pathways, i.e. ERK and AKT, by nano-Et(3)PAuCl, was clearly documented. The implications of these findings are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10534-021-00313-0.
format Online
Article
Text
id pubmed-8313464
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-83134642021-08-16 Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles Menconi, Alessio Marzo, Tiziano Massai, Lara Pratesi, Alessandro Severi, Mirko Petroni, Giulia Antonuzzo, Lorenzo Messori, Luigi Pillozzi, Serena Cirri, Damiano Biometals Article Chloro(triethylphosphine)gold(I), (Et(3)PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties. Like AF, Et(3)PAuCl exhibits potent antiproliferative properties in vitro toward a variety of cancer cell lines and is a promising anticancer drug candidate. We wondered whether Et(3)PAuCl encapsulation might lead to an improved pharmacological profile also considering the likely reduction of unwanted side-reactions that are responsible for adverse effects and for drug inactivation. Et(3)PAuCl was encapsulated in biocompatible PLGA–PEG nanoparticles (NPs) and the new formulation evaluated in colorectal HCT-116 cancer cells in comparison to the free gold complex. Notably, encapsulated Et(3)PAuCl (nano-Et(3)PAuCl hereafter) mostly retains the cellular properties of the free gold complex and elicits even greater cytotoxic effects in colorectal cancer (CRC) cells, mediated by apoptosis and autophagy. Moreover, a remarkable inhibition of two crucial signaling pathways, i.e. ERK and AKT, by nano-Et(3)PAuCl, was clearly documented. The implications of these findings are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10534-021-00313-0. Springer Netherlands 2021-04-27 2021 /pmc/articles/PMC8313464/ /pubmed/33907910 http://dx.doi.org/10.1007/s10534-021-00313-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Menconi, Alessio
Marzo, Tiziano
Massai, Lara
Pratesi, Alessandro
Severi, Mirko
Petroni, Giulia
Antonuzzo, Lorenzo
Messori, Luigi
Pillozzi, Serena
Cirri, Damiano
Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
title Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
title_full Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
title_fullStr Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
title_full_unstemmed Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
title_short Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles
title_sort anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(i) encapsulated in plga–peg nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313464/
https://www.ncbi.nlm.nih.gov/pubmed/33907910
http://dx.doi.org/10.1007/s10534-021-00313-0
work_keys_str_mv AT menconialessio anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT marzotiziano anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT massailara anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT pratesialessandro anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT severimirko anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT petronigiulia anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT antonuzzolorenzo anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT messoriluigi anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT pillozziserena anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles
AT cirridamiano anticancereffectsagainstcolorectalcancermodelsofchlorotriethylphosphinegoldiencapsulatedinplgapegnanoparticles