Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’

The in vivo phenotypic profile of T cells reactive to severe acute respiratory syndrome (SARS)-CoV-2 antigens remains poorly understood. Conventional methods to detect antigen-reactive T cells require in vitro antigenic re-stimulation or highly individualized peptide-human leukocyte antigen (pHLA) m...

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Detalles Bibliográficos
Autores principales: Fischer, David S., Ansari, Meshal, Wagner, Karolin I., Jarosch, Sebastian, Huang, Yiqi, Mayr, Christoph H., Strunz, Maximilian, Lang, Niklas J., D’Ippolito, Elvira, Hammel, Monika, Mateyka, Laura, Weber, Simone, Wolff, Lisa S., Witter, Klaus, Fernandez, Isis E., Leuschner, Gabriela, Milger, Katrin, Frankenberger, Marion, Nowak, Lorenz, Heinig-Menhard, Katharina, Koch, Ina, Stoleriu, Mircea G., Hilgendorff, Anne, Behr, Jürgen, Pichlmair, Andreas, Schubert, Benjamin, Theis, Fabian J., Busch, Dirk H., Schiller, Herbert B., Schober, Kilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313584/
https://www.ncbi.nlm.nih.gov/pubmed/34312385
http://dx.doi.org/10.1038/s41467-021-24730-4

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