Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

The human cytidine deaminase family of APOBEC3s (A3s) plays critical roles in both innate immunity and the development of cancers. A3s comprise seven functionally overlapping but distinct members that can be exploited as nucleotide base editors for treating genetic diseases. Although overall structu...

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Detalles Bibliográficos
Autores principales: Hou, Shurong, Lee, Jeong Min, Myint, Wazo, Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
ASBMB Award Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313598/
https://www.ncbi.nlm.nih.gov/pubmed/34171358
http://dx.doi.org/10.1016/j.jbc.2021.100909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313598/
https://www.ncbi.nlm.nih.gov/pubmed/34171358
http://dx.doi.org/10.1016/j.jbc.2021.100909

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