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Lead exposure is associated with functional and microstructural changes in the healthy human brain

Lead is a toxin known to harm many organs in the body, particularly the central nervous system, across an individual’s lifespan. To date, no study has yet investigated the associations between body lead level and the microstructural properties of gray matter areas, and brain activity during attentio...

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Autores principales: Takeuchi, Hikaru, Taki, Yasuyuki, Nouchi, Rui, Yokoyama, Ryoichi, Kotozaki, Yuka, Nakagawa, Seishu, Sekiguchi, Atsushi, Iizuka, Kunio, Hanawa, Sugiko, Araki, Tsuyoshi, Miyauchi, Carlos Makoto, Sakaki, Kohei, Nozawa, Takayuki, Ikeda, Shigeyuki, Yokota, Susum, Daniele, Magistro, Sassa, Yuko, Kawashima, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313694/
https://www.ncbi.nlm.nih.gov/pubmed/34312468
http://dx.doi.org/10.1038/s42003-021-02435-0
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author Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Sakaki, Kohei
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susum
Daniele, Magistro
Sassa, Yuko
Kawashima, Ryuta
author_facet Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Sakaki, Kohei
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susum
Daniele, Magistro
Sassa, Yuko
Kawashima, Ryuta
author_sort Takeuchi, Hikaru
collection PubMed
description Lead is a toxin known to harm many organs in the body, particularly the central nervous system, across an individual’s lifespan. To date, no study has yet investigated the associations between body lead level and the microstructural properties of gray matter areas, and brain activity during attention-demanding tasks. Here, utilizing data of diffusion tensor imaging, functional magnetic resonance imaging and cognitive measures among 920 typically developing young adults, we show greater hair lead levels are weakly but significantly associated with (a) increased working memory-related activity in the right premotor and pre-supplemental motor areas, (b) lower fractional anisotropy (FA) in white matter areas near the internal capsule, (c) lower mean diffusivity (MD) in the dopaminergic system in the left hemisphere and other widespread contingent areas, and (d) greater MD in the white matter area adjacent to the right fusiform gyrus. Higher lead levels were also weakly but significantly associated with lower performance in tests of high-order cognitive functions, such as the psychometric intelligence test, greater impulsivity measures, and higher novelty seeking and extraversion. These findings reflect the weak effect of daily lead level on the excitability and microstructural properties of the brain, particularly in the dopaminergic system.
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spelling pubmed-83136942021-08-03 Lead exposure is associated with functional and microstructural changes in the healthy human brain Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Yokoyama, Ryoichi Kotozaki, Yuka Nakagawa, Seishu Sekiguchi, Atsushi Iizuka, Kunio Hanawa, Sugiko Araki, Tsuyoshi Miyauchi, Carlos Makoto Sakaki, Kohei Nozawa, Takayuki Ikeda, Shigeyuki Yokota, Susum Daniele, Magistro Sassa, Yuko Kawashima, Ryuta Commun Biol Article Lead is a toxin known to harm many organs in the body, particularly the central nervous system, across an individual’s lifespan. To date, no study has yet investigated the associations between body lead level and the microstructural properties of gray matter areas, and brain activity during attention-demanding tasks. Here, utilizing data of diffusion tensor imaging, functional magnetic resonance imaging and cognitive measures among 920 typically developing young adults, we show greater hair lead levels are weakly but significantly associated with (a) increased working memory-related activity in the right premotor and pre-supplemental motor areas, (b) lower fractional anisotropy (FA) in white matter areas near the internal capsule, (c) lower mean diffusivity (MD) in the dopaminergic system in the left hemisphere and other widespread contingent areas, and (d) greater MD in the white matter area adjacent to the right fusiform gyrus. Higher lead levels were also weakly but significantly associated with lower performance in tests of high-order cognitive functions, such as the psychometric intelligence test, greater impulsivity measures, and higher novelty seeking and extraversion. These findings reflect the weak effect of daily lead level on the excitability and microstructural properties of the brain, particularly in the dopaminergic system. Nature Publishing Group UK 2021-07-26 /pmc/articles/PMC8313694/ /pubmed/34312468 http://dx.doi.org/10.1038/s42003-021-02435-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Hanawa, Sugiko
Araki, Tsuyoshi
Miyauchi, Carlos Makoto
Sakaki, Kohei
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susum
Daniele, Magistro
Sassa, Yuko
Kawashima, Ryuta
Lead exposure is associated with functional and microstructural changes in the healthy human brain
title Lead exposure is associated with functional and microstructural changes in the healthy human brain
title_full Lead exposure is associated with functional and microstructural changes in the healthy human brain
title_fullStr Lead exposure is associated with functional and microstructural changes in the healthy human brain
title_full_unstemmed Lead exposure is associated with functional and microstructural changes in the healthy human brain
title_short Lead exposure is associated with functional and microstructural changes in the healthy human brain
title_sort lead exposure is associated with functional and microstructural changes in the healthy human brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313694/
https://www.ncbi.nlm.nih.gov/pubmed/34312468
http://dx.doi.org/10.1038/s42003-021-02435-0
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