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Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surve...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313704/ https://www.ncbi.nlm.nih.gov/pubmed/34312420 http://dx.doi.org/10.1038/s41598-021-94509-6 |
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author | Parisse, Simona Ferri, Flaminia Persichetti, Marzia Mischitelli, Monica Abbatecola, Aurelio Di Martino, Michele Lai, Quirino Carnevale, Sara Lucatelli, Pierleone Bezzi, Mario Rossi, Massimo De Santis, Adriano Spagnoli, Alessandra Ginanni Corradini, Stefano |
author_facet | Parisse, Simona Ferri, Flaminia Persichetti, Marzia Mischitelli, Monica Abbatecola, Aurelio Di Martino, Michele Lai, Quirino Carnevale, Sara Lucatelli, Pierleone Bezzi, Mario Rossi, Massimo De Santis, Adriano Spagnoli, Alessandra Ginanni Corradini, Stefano |
author_sort | Parisse, Simona |
collection | PubMed |
description | This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels. |
format | Online Article Text |
id | pubmed-8313704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83137042021-07-28 Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients Parisse, Simona Ferri, Flaminia Persichetti, Marzia Mischitelli, Monica Abbatecola, Aurelio Di Martino, Michele Lai, Quirino Carnevale, Sara Lucatelli, Pierleone Bezzi, Mario Rossi, Massimo De Santis, Adriano Spagnoli, Alessandra Ginanni Corradini, Stefano Sci Rep Article This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels. Nature Publishing Group UK 2021-07-26 /pmc/articles/PMC8313704/ /pubmed/34312420 http://dx.doi.org/10.1038/s41598-021-94509-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Parisse, Simona Ferri, Flaminia Persichetti, Marzia Mischitelli, Monica Abbatecola, Aurelio Di Martino, Michele Lai, Quirino Carnevale, Sara Lucatelli, Pierleone Bezzi, Mario Rossi, Massimo De Santis, Adriano Spagnoli, Alessandra Ginanni Corradini, Stefano Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
title | Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
title_full | Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
title_fullStr | Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
title_full_unstemmed | Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
title_short | Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
title_sort | low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313704/ https://www.ncbi.nlm.nih.gov/pubmed/34312420 http://dx.doi.org/10.1038/s41598-021-94509-6 |
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