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Role of cholesterol in substrate recognition by [Formula: see text] -secretase

[Formula: see text] -Secretase is an enzyme known to cleave multiple substrates within their transmembrane domains, with the amyloid precursor protein of Alzheimer’s Disease among the most prominent examples. The activity of [Formula: see text] -secretase strictly depends on the membrane cholesterol...

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Detalles Bibliográficos
Autores principales:	Nierzwicki, Łukasz, Olewniczak, Michał, Chodnicki, Paweł, Czub, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313713/ https://www.ncbi.nlm.nih.gov/pubmed/34312439 http://dx.doi.org/10.1038/s41598-021-94618-2

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