Cargando…

MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress

Poly (ADP-ribose) polymerase (PARP) inhibitor olaparib selectively kills cancer cells with BRCA-deficiency and is approved for BRCA-mutated breast, ovarian and pancreatic cancers by FDA. However, phase III study of olaparib failed to show a significant improvement in overall survival in patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Jinwen, Zhang, Xiaofeng, Li, Jin'e, Huang, Wenwen, Wang, Yini, Wang, Yi, Qin, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313750/ https://www.ncbi.nlm.nih.gov/pubmed/34280886 http://dx.doi.org/10.1016/j.tranon.2021.101167

Ejemplares similares

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
por: King, David, et al.
Publicado: (2020)

Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
por: King, David, et al.
Publicado: (2023)

RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping
por: Zamalloa, Luis Gregory, et al.
Publicado: (2023)

PARP inhibition impedes the maturation of nascent DNA strands during DNA replication
por: Vaitsiankova, Alina, et al.
Publicado: (2022)

Structural basis for MTA1c-mediated DNA N6-adenine methylation
por: Chen, Jiyun, et al.
Publicado: (2022)

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response
por: Bland, Philip, et al.
Publicado: (2023)

TRLS-14. TARGETING REPLICATIVE STRESS IN BRAIN TUMORS BY COMBINING ATR AND PARP INHIBITION
por: Sarvode, Supriya, et al.
Publicado: (2023)

Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment
por: Li, Yuan, et al.
Publicado: (2019)

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
por: Aguilar-Quesada, Rocío, et al.
Publicado: (2007)

The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress
por: Ganz, Magdalena, et al.
Publicado: (2019)

PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair
por: Ho, Yen-Chih, et al.
Publicado: (2022)

PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy
por: Bian, X, et al.
Publicado: (2018)

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA
por: Alimohammadi, Marzieh, et al.
Publicado: (2021)

Mta2 promotes Tipin-dependent maintenance of replication fork integrity
por: Errico, Alessia, et al.
Publicado: (2014)

ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition
por: Giovannini, Sara, et al.
Publicado: (2020)

Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer
por: Guo, Yuchen, et al.
Publicado: (2021)

Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation
por: Zhang, Long, et al.
Publicado: (2019)

ARF induction in response to DNA strand breaks is regulated by PARP1
por: Orlando, Giulia, et al.
Publicado: (2014)

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
por: Serrano‐Benitez, Almudena, et al.
Publicado: (2023)

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress
por: Schleicher, Emily M, et al.
Publicado: (2018)

RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma
por: Zhang, Jing, et al.
Publicado: (2021)

PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in Glioblastoma
por: Karpel-Massler, Georg, et al.
Publicado: (2014)

miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2
por: An, Jia-Xiang, et al.
Publicado: (2018)

Comparison of Antibacterial Activities of ProRoot MTA, OrthoMTA, and RetroMTA Against Three Anaerobic Endodontic Bacteria
por: Khedmat, Sedigheh, et al.
Publicado: (2018)

PARP1 proximity proteomics reveals interaction partners at stressed replication forks
por: Mosler, Thorsten, et al.
Publicado: (2022)

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
por: Wurster, Stephanie, et al.
Publicado: (2016)

Deconvolution of the particle size distribution of ProRoot MTA and MTA Angelus
por: Ha, William Nguyen, et al.
Publicado: (2016)

MTA1 promotes proliferation and invasion in human gastric cancer cells
por: Yao, Yuan, et al.
Publicado: (2015)

Evaluation of the cytotoxic effects of a new Harvard MTA compared to MTA Flow and ProRoot MTA on human gingival fibroblasts
por: Youssef, Abdel-Rahman, et al.
Publicado: (2021)

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA
por: Sugimura, Kazuto, et al.
Publicado: (2008)

Capitalizing on ATRX loss in glioma via PARP inhibition: Comment on “Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity” by Garbarino et al.
por: Zalenski, Abigail A, et al.
Publicado: (2021)

Clinical studies with MTA.
por: Calvert, A. H., et al.
Publicado: (1998)

Setting time of MTA
por: Hwang, Yun-Chan
Publicado: (2014)

Inhibition of DNA damage repair by artificial activation of PARP with siDNA
por: Croset, Amelie, et al.
Publicado: (2013)

miR-30 inhibits the progression of osteosarcoma by targeting MTA1
por: Zhao, Aiqing, et al.
Publicado: (2022)

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
por: Gemble, Simon, et al.
Publicado: (2015)

Structural insights into DNA N(6)-adenine methylation by the MTA1 complex
por: Yan, Junjun, et al.
Publicado: (2023)

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
por: Garbarino, Jennifer, et al.
Publicado: (2021)

MTA1 promotes proliferation and invasion in human gastric cancer cells [Retraction]
Publicado: (2017)

Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan
por: Abu-Sanad, Atlal, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dl4sr5be4d7q6ples4oimbf7iv