Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative effect of tankyrase inhibition (TNKSi). The TNKS1/2-speci...

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Detalles Bibliográficos
Autores principales: Mygland, Line, Brinch, Shoshy Alam, Strand, Martin Frank, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Lund, Kaja, Solberg, Nina Therese, Lycke, Max, Thorvaldsen, Tor Espen, Espada, Sandra, Misaghian, Dorna, Page, Christian M., Agafonov, Oleg, Nygård, Ståle, Chi, Nai-Wen, Lin, Eva, Tan, Jenille, Yu, Yihong, Costa, Mike, Krauss, Stefan, Waaler, Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
https://www.ncbi.nlm.nih.gov/pubmed/34337362
http://dx.doi.org/10.1016/j.isci.2021.102807

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