Cargando…

Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women

The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21–40 years old) who were apparently healthy were recruited from the local community (ClinicalTrials.gov trial registration NCT03828097). Pretesting...

Descripción completa

Detalles Bibliográficos
Autores principales: Osburn, Shelby C., Roberson, Paul A., Medler, Jessica A., Shake, Jacob, Arnold, Robert D., Alamdari, Nima, Bucci, Luke R., Vance, Arianne, Sharafi, Mastaneh, Young, Kaelin C., Roberts, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313763/
https://www.ncbi.nlm.nih.gov/pubmed/34327207
http://dx.doi.org/10.3389/fnut.2021.610382
_version_ 1783729413505941504
author Osburn, Shelby C.
Roberson, Paul A.
Medler, Jessica A.
Shake, Jacob
Arnold, Robert D.
Alamdari, Nima
Bucci, Luke R.
Vance, Arianne
Sharafi, Mastaneh
Young, Kaelin C.
Roberts, Michael D.
author_facet Osburn, Shelby C.
Roberson, Paul A.
Medler, Jessica A.
Shake, Jacob
Arnold, Robert D.
Alamdari, Nima
Bucci, Luke R.
Vance, Arianne
Sharafi, Mastaneh
Young, Kaelin C.
Roberts, Michael D.
author_sort Osburn, Shelby C.
collection PubMed
description The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21–40 years old) who were apparently healthy were recruited from the local community (ClinicalTrials.gov trial registration NCT03828097). Pretesting (PRE) occurred in the morning 5 ± 2 days following each participant's menses and involved a fasted blood draw, body mass assessment, and blood pressure assessment. Participants were then randomly assigned in a double-blinded fashion to either the multivitamins (MV) (n = 43) or placebo group (n = 51). Participants consumed two capsules per day with breakfast for 12 weeks. Following the trial, participants reported to the laboratory for POST assessments, which replicated PRE procedures. Red blood cell fatty acid and serum micronutrient analyses were performed in a blinded fashion at hematology laboratories. A group × time interaction was observed for serum vitamin D levels (p < 0.001). MV increased levels from PRE to POST (+43.7%, p < 0.001), whereas no change occurred in the placebo group. Additionally, 78% of MV participants at PRE exhibited inadequate vitamin D levels (<40 ng/dl), whereas only 30% exhibited levels below this threshold at POST. An interaction was also observed for serum folate levels (p < 0.001). MV increased serum folate from PRE to POST (p < 0.001), whereas no change occurred in the placebo group. Red blood cell omega-3 fatty acid content increased from PRE to POST in the MV group (p < 0.001) and placebo group (p < 0.05), although POST values were greater in the MV group (p < 0.001). An interaction was observed for serum HDL cholesterol levels (p = 0.047), and a non-significant increase in this variable from PRE to POST occurred in the MV group (p = 0.060). Four-day food recalls indicated MV increased intake of omega-3 fatty acids, vitamin D, folate, and other micronutrients. In summary, MV supplementation increased serum vitamin D, serum folate, and red blood cell omega-3 fatty acid levels. However, these data are limited to healthy females, and more research is needed to examine if MV can affect metabolic disturbances in individuals with micronutrient deficiencies.
format Online
Article
Text
id pubmed-8313763
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83137632021-07-28 Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women Osburn, Shelby C. Roberson, Paul A. Medler, Jessica A. Shake, Jacob Arnold, Robert D. Alamdari, Nima Bucci, Luke R. Vance, Arianne Sharafi, Mastaneh Young, Kaelin C. Roberts, Michael D. Front Nutr Nutrition The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21–40 years old) who were apparently healthy were recruited from the local community (ClinicalTrials.gov trial registration NCT03828097). Pretesting (PRE) occurred in the morning 5 ± 2 days following each participant's menses and involved a fasted blood draw, body mass assessment, and blood pressure assessment. Participants were then randomly assigned in a double-blinded fashion to either the multivitamins (MV) (n = 43) or placebo group (n = 51). Participants consumed two capsules per day with breakfast for 12 weeks. Following the trial, participants reported to the laboratory for POST assessments, which replicated PRE procedures. Red blood cell fatty acid and serum micronutrient analyses were performed in a blinded fashion at hematology laboratories. A group × time interaction was observed for serum vitamin D levels (p < 0.001). MV increased levels from PRE to POST (+43.7%, p < 0.001), whereas no change occurred in the placebo group. Additionally, 78% of MV participants at PRE exhibited inadequate vitamin D levels (<40 ng/dl), whereas only 30% exhibited levels below this threshold at POST. An interaction was also observed for serum folate levels (p < 0.001). MV increased serum folate from PRE to POST (p < 0.001), whereas no change occurred in the placebo group. Red blood cell omega-3 fatty acid content increased from PRE to POST in the MV group (p < 0.001) and placebo group (p < 0.05), although POST values were greater in the MV group (p < 0.001). An interaction was observed for serum HDL cholesterol levels (p = 0.047), and a non-significant increase in this variable from PRE to POST occurred in the MV group (p = 0.060). Four-day food recalls indicated MV increased intake of omega-3 fatty acids, vitamin D, folate, and other micronutrients. In summary, MV supplementation increased serum vitamin D, serum folate, and red blood cell omega-3 fatty acid levels. However, these data are limited to healthy females, and more research is needed to examine if MV can affect metabolic disturbances in individuals with micronutrient deficiencies. Frontiers Media S.A. 2021-07-13 /pmc/articles/PMC8313763/ /pubmed/34327207 http://dx.doi.org/10.3389/fnut.2021.610382 Text en Copyright © 2021 Osburn, Roberson, Medler, Shake, Arnold, Alamdari, Bucci, Vance, Sharafi, Young and Roberts. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Osburn, Shelby C.
Roberson, Paul A.
Medler, Jessica A.
Shake, Jacob
Arnold, Robert D.
Alamdari, Nima
Bucci, Luke R.
Vance, Arianne
Sharafi, Mastaneh
Young, Kaelin C.
Roberts, Michael D.
Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
title Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
title_full Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
title_fullStr Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
title_full_unstemmed Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
title_short Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women
title_sort effects of 12-week multivitamin and omega-3 supplementation on micronutrient levels and red blood cell fatty acids in pre-menopausal women
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313763/
https://www.ncbi.nlm.nih.gov/pubmed/34327207
http://dx.doi.org/10.3389/fnut.2021.610382
work_keys_str_mv AT osburnshelbyc effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT robersonpaula effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT medlerjessicaa effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT shakejacob effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT arnoldrobertd effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT alamdarinima effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT bucciluker effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT vancearianne effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT sharafimastaneh effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT youngkaelinc effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen
AT robertsmichaeld effectsof12weekmultivitaminandomega3supplementationonmicronutrientlevelsandredbloodcellfattyacidsinpremenopausalwomen