A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons

Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduces α-synuclein aggregation in vitro and in a fruit fly...

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Detalles Bibliográficos
Autores principales: Szegő, Éva M., Boß, Fabian, Komnig, Daniel, Gärtner, Charlott, Höfs, Lennart, Shaykhalishahi, Hamed, Wördehoff, Michael M., Saridaki, Theodora, Schulz, Jörg B., Hoyer, Wolfgang, Falkenburger, Björn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313869/
https://www.ncbi.nlm.nih.gov/pubmed/34326719
http://dx.doi.org/10.3389/fnins.2021.696440

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