Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia

Hyperkalemia is a challenging comorbidity to manage in patients with heart failure and chronic kidney disease, particularly when administering renin-angiotensin-aldosterone system inhibitors. We encountered an 88-year-old woman with hypertensive heart failure and chronic kidney disease. A mineraloco...

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Autores principales: Imamura, Teruhiko, Oshima, Akira, Narang, Nikhil, Ushijima, Ryuichi, Ueno, Yohei, Ueno, Hiroshi, Kinugawa, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313903/
https://www.ncbi.nlm.nih.gov/pubmed/34193775
http://dx.doi.org/10.2169/internalmedicine.6704-20
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author Imamura, Teruhiko
Oshima, Akira
Narang, Nikhil
Ushijima, Ryuichi
Ueno, Yohei
Ueno, Hiroshi
Kinugawa, Koichiro
author_facet Imamura, Teruhiko
Oshima, Akira
Narang, Nikhil
Ushijima, Ryuichi
Ueno, Yohei
Ueno, Hiroshi
Kinugawa, Koichiro
author_sort Imamura, Teruhiko
collection PubMed
description Hyperkalemia is a challenging comorbidity to manage in patients with heart failure and chronic kidney disease, particularly when administering renin-angiotensin-aldosterone system inhibitors. We encountered an 88-year-old woman with hypertensive heart failure and chronic kidney disease. A mineralocorticoid receptor antagonist was able to be safely administered despite persistent hyperkalemia when sodium zirconium cyclosilicate, a non-absorbed, non-polymer zirconium silicate compound that preferentially exchanges hydrogen and sodium for potassium and ammonium ions in the gastrointestinal tract, was concomitantly administered. Sodium zirconium cyclosilicate might be a promising therapeutic tool to use in order to administer mineralocorticoid receptor antagonist safely in patients with heart failure, chronic kidney disease, and hyperkalemia.
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spelling pubmed-83139032021-08-11 Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia Imamura, Teruhiko Oshima, Akira Narang, Nikhil Ushijima, Ryuichi Ueno, Yohei Ueno, Hiroshi Kinugawa, Koichiro Intern Med Case Report Hyperkalemia is a challenging comorbidity to manage in patients with heart failure and chronic kidney disease, particularly when administering renin-angiotensin-aldosterone system inhibitors. We encountered an 88-year-old woman with hypertensive heart failure and chronic kidney disease. A mineralocorticoid receptor antagonist was able to be safely administered despite persistent hyperkalemia when sodium zirconium cyclosilicate, a non-absorbed, non-polymer zirconium silicate compound that preferentially exchanges hydrogen and sodium for potassium and ammonium ions in the gastrointestinal tract, was concomitantly administered. Sodium zirconium cyclosilicate might be a promising therapeutic tool to use in order to administer mineralocorticoid receptor antagonist safely in patients with heart failure, chronic kidney disease, and hyperkalemia. The Japanese Society of Internal Medicine 2021-07-01 2021-07-01 /pmc/articles/PMC8313903/ /pubmed/34193775 http://dx.doi.org/10.2169/internalmedicine.6704-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Imamura, Teruhiko
Oshima, Akira
Narang, Nikhil
Ushijima, Ryuichi
Ueno, Yohei
Ueno, Hiroshi
Kinugawa, Koichiro
Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia
title Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia
title_full Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia
title_fullStr Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia
title_full_unstemmed Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia
title_short Combination Therapy Using Sodium Zirconium Cyclosilicate and a Mineralocorticoid Receptor Antagonist in Patients with Heart Failure and Hyperkalemia
title_sort combination therapy using sodium zirconium cyclosilicate and a mineralocorticoid receptor antagonist in patients with heart failure and hyperkalemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313903/
https://www.ncbi.nlm.nih.gov/pubmed/34193775
http://dx.doi.org/10.2169/internalmedicine.6704-20
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