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COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series
BACKGROUND: A variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asympto...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314085/ https://www.ncbi.nlm.nih.gov/pubmed/34336629 http://dx.doi.org/10.5812/aapm.113760 |
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author | Papa, Alfonso Salzano, Anna Maria Di Dato, Maria Teresa Lo Bianco, Giuliano Tedesco, Mariangela Salzano, Antonio Myrcik, Dariusz Imani, Farnad Varrassi, Giustino Akhavan Akbari, Ghodrat Paladini, Antonella |
author_facet | Papa, Alfonso Salzano, Anna Maria Di Dato, Maria Teresa Lo Bianco, Giuliano Tedesco, Mariangela Salzano, Antonio Myrcik, Dariusz Imani, Farnad Varrassi, Giustino Akhavan Akbari, Ghodrat Paladini, Antonella |
author_sort | Papa, Alfonso |
collection | PubMed |
description | BACKGROUND: A variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asymptomatic and mildly symptomatic pediatric COVID-19 positive patients, without a precise pathogenetic mechanism. COVID-19-induced chilblains may portend an indolent course and a good outcome. In young patients, the IFN-1 response induces microangiopathic changes and produces a chilblain lupus erythematosus-like eruption with vasculitic neuropathic pain features. OBJECTIVES: This paper presented a case series of pediatric patients with COVID-19-related skin lesions and neuropathic-like pain. METHODS: Clinical outcomes were collected from 11 patients diagnosed with painful erythematous skin lesions with neuropathic-like pain and positive IgG for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RESULTS: It is a mildly symptomatic condition not related to severe pain rates, and it is treated with paracetamol due to the transitory nature of the problem, which provides good results. CONCLUSIONS: A particular point of interest is skin lesion manifestation as a further indirect sign of SARS-CoV-2 infection. Due to the initial manifestation of chilblains in pauci-symptomatic pediatric patients, they need to be immediately tested and isolated. Chilblains can be considered a clinical clue to suspect SARS-CoV-2 infection and help in early diagnosis, patient triage, and infection control. |
format | Online Article Text |
id | pubmed-8314085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-83140852021-07-29 COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series Papa, Alfonso Salzano, Anna Maria Di Dato, Maria Teresa Lo Bianco, Giuliano Tedesco, Mariangela Salzano, Antonio Myrcik, Dariusz Imani, Farnad Varrassi, Giustino Akhavan Akbari, Ghodrat Paladini, Antonella Anesth Pain Med Research Article BACKGROUND: A variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asymptomatic and mildly symptomatic pediatric COVID-19 positive patients, without a precise pathogenetic mechanism. COVID-19-induced chilblains may portend an indolent course and a good outcome. In young patients, the IFN-1 response induces microangiopathic changes and produces a chilblain lupus erythematosus-like eruption with vasculitic neuropathic pain features. OBJECTIVES: This paper presented a case series of pediatric patients with COVID-19-related skin lesions and neuropathic-like pain. METHODS: Clinical outcomes were collected from 11 patients diagnosed with painful erythematous skin lesions with neuropathic-like pain and positive IgG for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RESULTS: It is a mildly symptomatic condition not related to severe pain rates, and it is treated with paracetamol due to the transitory nature of the problem, which provides good results. CONCLUSIONS: A particular point of interest is skin lesion manifestation as a further indirect sign of SARS-CoV-2 infection. Due to the initial manifestation of chilblains in pauci-symptomatic pediatric patients, they need to be immediately tested and isolated. Chilblains can be considered a clinical clue to suspect SARS-CoV-2 infection and help in early diagnosis, patient triage, and infection control. Kowsar 2021-04-18 /pmc/articles/PMC8314085/ /pubmed/34336629 http://dx.doi.org/10.5812/aapm.113760 Text en Copyright © 2021, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Papa, Alfonso Salzano, Anna Maria Di Dato, Maria Teresa Lo Bianco, Giuliano Tedesco, Mariangela Salzano, Antonio Myrcik, Dariusz Imani, Farnad Varrassi, Giustino Akhavan Akbari, Ghodrat Paladini, Antonella COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series |
title | COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series |
title_full | COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series |
title_fullStr | COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series |
title_full_unstemmed | COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series |
title_short | COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series |
title_sort | covid-19 related acro-ischemic neuropathic-like painful lesions in pediatric patients: a case series |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314085/ https://www.ncbi.nlm.nih.gov/pubmed/34336629 http://dx.doi.org/10.5812/aapm.113760 |
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