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Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017
OBJECTIVES: Data on antibiotic consumption in the community were collected from 30 EU/EEA countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes in the composition of the main antibiotic groups. METHODS: For the period 1997–2017, d...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314117/ https://www.ncbi.nlm.nih.gov/pubmed/34312654 http://dx.doi.org/10.1093/jac/dkab172 |
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author | Bruyndonckx, Robin Adriaenssens, Niels Versporten, Ann Hens, Niel Monnet, Dominique L Molenberghs, Geert Goossens, Herman Weist, Klaus Coenen, Samuel |
author_facet | Bruyndonckx, Robin Adriaenssens, Niels Versporten, Ann Hens, Niel Monnet, Dominique L Molenberghs, Geert Goossens, Herman Weist, Klaus Coenen, Samuel |
author_sort | Bruyndonckx, Robin |
collection | PubMed |
description | OBJECTIVES: Data on antibiotic consumption in the community were collected from 30 EU/EEA countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes in the composition of the main antibiotic groups. METHODS: For the period 1997–2017, data on consumption of antibiotics, i.e. antibacterials for systemic use (ATC group J01), in the community, aggregated at the level of the active substance, were collected using the WHO ATC/DDD methodology (ATC/DDD index 2019). Consumption was expressed in DDD per 1000 inhabitants per day and in packages per 1000 inhabitants per day. Antibiotic consumption was analysed based on ATC-3 groups, and presented as trends, seasonal variation, presence of change-points and compositional changes. RESULTS: In 2017, antibiotic consumption in the community expressed in DDD per 1000 inhabitants per day varied by a factor 3.6 between countries with the highest (Greece) and the lowest (the Netherlands) consumption. Antibiotic consumption in the EU/EEA did not change significantly over time. Antibiotic consumption showed a significant seasonal variation, which decreased over time. The number of DDD per package significantly increased over time. The proportional consumption of sulphonamides and trimethoprim (J01E) relative to other groups significantly decreased over time, while the proportional consumption of other antibacterials (J01X) relative to other groups significantly increased over time. CONCLUSIONS: Overall, antibiotic consumption in the community in the EU/EEA did not change during 1997–2017, while seasonal variation consistently decreased over time. The number of DDD per package increased during 1997–2017. |
format | Online Article Text |
id | pubmed-8314117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-83141172021-07-27 Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 Bruyndonckx, Robin Adriaenssens, Niels Versporten, Ann Hens, Niel Monnet, Dominique L Molenberghs, Geert Goossens, Herman Weist, Klaus Coenen, Samuel J Antimicrob Chemother Supplement Papers OBJECTIVES: Data on antibiotic consumption in the community were collected from 30 EU/EEA countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes in the composition of the main antibiotic groups. METHODS: For the period 1997–2017, data on consumption of antibiotics, i.e. antibacterials for systemic use (ATC group J01), in the community, aggregated at the level of the active substance, were collected using the WHO ATC/DDD methodology (ATC/DDD index 2019). Consumption was expressed in DDD per 1000 inhabitants per day and in packages per 1000 inhabitants per day. Antibiotic consumption was analysed based on ATC-3 groups, and presented as trends, seasonal variation, presence of change-points and compositional changes. RESULTS: In 2017, antibiotic consumption in the community expressed in DDD per 1000 inhabitants per day varied by a factor 3.6 between countries with the highest (Greece) and the lowest (the Netherlands) consumption. Antibiotic consumption in the EU/EEA did not change significantly over time. Antibiotic consumption showed a significant seasonal variation, which decreased over time. The number of DDD per package significantly increased over time. The proportional consumption of sulphonamides and trimethoprim (J01E) relative to other groups significantly decreased over time, while the proportional consumption of other antibacterials (J01X) relative to other groups significantly increased over time. CONCLUSIONS: Overall, antibiotic consumption in the community in the EU/EEA did not change during 1997–2017, while seasonal variation consistently decreased over time. The number of DDD per package increased during 1997–2017. Oxford University Press 2021-08-01 /pmc/articles/PMC8314117/ /pubmed/34312654 http://dx.doi.org/10.1093/jac/dkab172 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Supplement Papers Bruyndonckx, Robin Adriaenssens, Niels Versporten, Ann Hens, Niel Monnet, Dominique L Molenberghs, Geert Goossens, Herman Weist, Klaus Coenen, Samuel Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 |
title | Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 |
title_full | Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 |
title_fullStr | Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 |
title_full_unstemmed | Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 |
title_short | Consumption of antibiotics in the community, European Union/European Economic Area, 1997–2017 |
title_sort | consumption of antibiotics in the community, european union/european economic area, 1997–2017 |
topic | Supplement Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314117/ https://www.ncbi.nlm.nih.gov/pubmed/34312654 http://dx.doi.org/10.1093/jac/dkab172 |
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