Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons

Pathogenic variants in SPG11 are the most frequent cause of autosomal recessive complicated hereditary spastic paraplegia (HSP). In addition to spastic paraplegia caused by corticospinal degeneration, most patients are significantly affected by progressive weakness and muscle wasting due to alpha mo...

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Detalles Bibliográficos
Autores principales: Güner, Fabian, Pozner, Tatyana, Krach, Florian, Prots, Iryna, Loskarn, Sandra, Schlötzer-Schrehardt, Ursula, Winkler, Jürgen, Winner, Beate, Regensburger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314181/
https://www.ncbi.nlm.nih.gov/pubmed/34326717
http://dx.doi.org/10.3389/fnins.2021.680572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314181/
https://www.ncbi.nlm.nih.gov/pubmed/34326717
http://dx.doi.org/10.3389/fnins.2021.680572

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