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Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?

INTRODUCTION: Autoimmune diseases concomitant with diabetes may complicate the treatment and adversely affect the prognosis. The most common is Hashimoto’s disease (HD). We compared diabetes control and prevalence of chronic complications in type 1 diabetes patients differing in the coexistence of H...

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Autores principales: Szcześniak, Grzegorz, Kozak-Nurczyk, Patrycja, Dziemidok, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314392/
https://www.ncbi.nlm.nih.gov/pubmed/34336018
http://dx.doi.org/10.5114/aoms.2019.89780
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author Szcześniak, Grzegorz
Kozak-Nurczyk, Patrycja
Dziemidok, Piotr
author_facet Szcześniak, Grzegorz
Kozak-Nurczyk, Patrycja
Dziemidok, Piotr
author_sort Szcześniak, Grzegorz
collection PubMed
description INTRODUCTION: Autoimmune diseases concomitant with diabetes may complicate the treatment and adversely affect the prognosis. The most common is Hashimoto’s disease (HD). We compared diabetes control and prevalence of chronic complications in type 1 diabetes patients differing in the coexistence of HD. MATERIAL AND METHODS: Medical records of 188 type 1 diabetics were analysed. Hashimoto’s disease was diagnosed based on medical history, as well as determination of the levels of thyroid peroxidase antibodies, hormones and ultrasound examination. Statistical analysis was performed using Statistica 10PL. RESULTS: HD was diagnosed in 43 (23%) patients. The mean HbA(1c) was 8.8 ±1.5% in the group with HD, and 9 ±1.6% in the group without HD (ns). The prevalence of diabetes complications was similar in both groups: ischaemic heart disease was diagnosed in 19% of patients with HD and 19% without HD, cerebral vascular insufficiency – 8% and 7%, peripheral neuropathy – 14% and 12%, sensory polyneuropathy – 47% and 46%, diabetic foot – 7% and 8%, Charcot osteoarthropathy – 7% and 2%, cardiovascular neuropathy – 21% and 28%, neuropathy of the gastrointestinal tract – 5% and 6%, nephropathy – 12% and 19%, retinopathy – 42% and 43%, and cataract in 28% and 19%, respectively. Impaired hypoglycaemia perception was rarer in the group with HD: 9% vs. 25% (p ≈ 0.04). CONCLUSIONS: Hashimoto’s disease does not significantly affect the level of type 1 diabetes control or the development of its complications. Only autonomic neuropathy in the form of impaired awareness of hypoglycaemia is rarer in patients with that thyroiditis.
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spelling pubmed-83143922021-07-31 Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications? Szcześniak, Grzegorz Kozak-Nurczyk, Patrycja Dziemidok, Piotr Arch Med Sci Clinical Research INTRODUCTION: Autoimmune diseases concomitant with diabetes may complicate the treatment and adversely affect the prognosis. The most common is Hashimoto’s disease (HD). We compared diabetes control and prevalence of chronic complications in type 1 diabetes patients differing in the coexistence of HD. MATERIAL AND METHODS: Medical records of 188 type 1 diabetics were analysed. Hashimoto’s disease was diagnosed based on medical history, as well as determination of the levels of thyroid peroxidase antibodies, hormones and ultrasound examination. Statistical analysis was performed using Statistica 10PL. RESULTS: HD was diagnosed in 43 (23%) patients. The mean HbA(1c) was 8.8 ±1.5% in the group with HD, and 9 ±1.6% in the group without HD (ns). The prevalence of diabetes complications was similar in both groups: ischaemic heart disease was diagnosed in 19% of patients with HD and 19% without HD, cerebral vascular insufficiency – 8% and 7%, peripheral neuropathy – 14% and 12%, sensory polyneuropathy – 47% and 46%, diabetic foot – 7% and 8%, Charcot osteoarthropathy – 7% and 2%, cardiovascular neuropathy – 21% and 28%, neuropathy of the gastrointestinal tract – 5% and 6%, nephropathy – 12% and 19%, retinopathy – 42% and 43%, and cataract in 28% and 19%, respectively. Impaired hypoglycaemia perception was rarer in the group with HD: 9% vs. 25% (p ≈ 0.04). CONCLUSIONS: Hashimoto’s disease does not significantly affect the level of type 1 diabetes control or the development of its complications. Only autonomic neuropathy in the form of impaired awareness of hypoglycaemia is rarer in patients with that thyroiditis. Termedia Publishing House 2019-11-16 /pmc/articles/PMC8314392/ /pubmed/34336018 http://dx.doi.org/10.5114/aoms.2019.89780 Text en Copyright: © 2019 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Szcześniak, Grzegorz
Kozak-Nurczyk, Patrycja
Dziemidok, Piotr
Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
title Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
title_full Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
title_fullStr Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
title_full_unstemmed Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
title_short Does concomitance of Hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
title_sort does concomitance of hashimoto’s disease and type 1 diabetes affect diabetes control and development of its complications?
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314392/
https://www.ncbi.nlm.nih.gov/pubmed/34336018
http://dx.doi.org/10.5114/aoms.2019.89780
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