Cargando…
The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography
INTRODUCTION: Periampullary diverticulum (PAD), although commonly discovered in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP), remains controversial regarding its role in pancreaticobiliary diseases and the failure rate of cannulation. The aim of this study was to evaluat...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314422/ https://www.ncbi.nlm.nih.gov/pubmed/34336019 http://dx.doi.org/10.5114/aoms.2020.94591 |
_version_ | 1783729550563213312 |
---|---|
author | Chen, Qiaofeng Zhang, Yuanyuan Tang, Zhihua Yu, Mingju Liu, Zhijian Zhou, Xiaojiang Li, Guohua Chen, Youxiang Zhou, Xiaodong |
author_facet | Chen, Qiaofeng Zhang, Yuanyuan Tang, Zhihua Yu, Mingju Liu, Zhijian Zhou, Xiaojiang Li, Guohua Chen, Youxiang Zhou, Xiaodong |
author_sort | Chen, Qiaofeng |
collection | PubMed |
description | INTRODUCTION: Periampullary diverticulum (PAD), although commonly discovered in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP), remains controversial regarding its role in pancreaticobiliary diseases and the failure rate of cannulation. The aim of this study was to evaluate the association of PAD with pancreaticobiliary diseases and its impact on the outcome of ERCP. MATERIAL AND METHODS: A retrospective analysis was carried out on 1455 patients who underwent an ERCP. Patients were divided into a PAD group and a control group without PAD, and propensity score matching was performed to adjust for clinical differences. The comparison was focused on pancreaticobiliary diseases, technical success, and complications of ERCP. RESULTS: The occurrence of PAD is associated significantly with increasing age (p < 0.001). Incidences of acute pancreatitis (AP), suppurative cholangitis, and pancreatic head cancer were significantly higher in the PAD group (p < 0.05). After propensity score matching, the PAD group exhibited a higher rate of post-ERCP complications including haemorrhage, post-ERCP pancreatitis (PEP), and hyperamylasaemia (p < 0.05). However, the prevalence of perforation and the success rate of ERCP did not differ between groups (p > 0.05). CONCLUSIONS: Periampullary diverticulum develops with aging and seems to be associated with an increase in pancreaticobiliary diseases and post-ERCP complications except for perforation. Additionally, the presence of PAD does not affect the technical success of ERCP. |
format | Online Article Text |
id | pubmed-8314422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-83144222021-07-31 The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography Chen, Qiaofeng Zhang, Yuanyuan Tang, Zhihua Yu, Mingju Liu, Zhijian Zhou, Xiaojiang Li, Guohua Chen, Youxiang Zhou, Xiaodong Arch Med Sci Clinical Research INTRODUCTION: Periampullary diverticulum (PAD), although commonly discovered in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP), remains controversial regarding its role in pancreaticobiliary diseases and the failure rate of cannulation. The aim of this study was to evaluate the association of PAD with pancreaticobiliary diseases and its impact on the outcome of ERCP. MATERIAL AND METHODS: A retrospective analysis was carried out on 1455 patients who underwent an ERCP. Patients were divided into a PAD group and a control group without PAD, and propensity score matching was performed to adjust for clinical differences. The comparison was focused on pancreaticobiliary diseases, technical success, and complications of ERCP. RESULTS: The occurrence of PAD is associated significantly with increasing age (p < 0.001). Incidences of acute pancreatitis (AP), suppurative cholangitis, and pancreatic head cancer were significantly higher in the PAD group (p < 0.05). After propensity score matching, the PAD group exhibited a higher rate of post-ERCP complications including haemorrhage, post-ERCP pancreatitis (PEP), and hyperamylasaemia (p < 0.05). However, the prevalence of perforation and the success rate of ERCP did not differ between groups (p > 0.05). CONCLUSIONS: Periampullary diverticulum develops with aging and seems to be associated with an increase in pancreaticobiliary diseases and post-ERCP complications except for perforation. Additionally, the presence of PAD does not affect the technical success of ERCP. Termedia Publishing House 2020-04-22 /pmc/articles/PMC8314422/ /pubmed/34336019 http://dx.doi.org/10.5114/aoms.2020.94591 Text en Copyright: © 2020 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Chen, Qiaofeng Zhang, Yuanyuan Tang, Zhihua Yu, Mingju Liu, Zhijian Zhou, Xiaojiang Li, Guohua Chen, Youxiang Zhou, Xiaodong The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
title | The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
title_full | The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
title_fullStr | The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
title_full_unstemmed | The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
title_short | The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
title_sort | role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314422/ https://www.ncbi.nlm.nih.gov/pubmed/34336019 http://dx.doi.org/10.5114/aoms.2020.94591 |
work_keys_str_mv | AT chenqiaofeng theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT zhangyuanyuan theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT tangzhihua theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT yumingju theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT liuzhijian theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT zhouxiaojiang theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT liguohua theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT chenyouxiang theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT zhouxiaodong theroleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT chenqiaofeng roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT zhangyuanyuan roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT tangzhihua roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT yumingju roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT liuzhijian roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT zhouxiaojiang roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT liguohua roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT chenyouxiang roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography AT zhouxiaodong roleofperiampullarydiverticulumontheincidenceofpancreaticobiliarydiseasesandtheoutcomeofendoscopicretrogradecholangiopancreatography |