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Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RN...

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Autores principales: Chen, Xuechai, Wang, Jianan, Tahir, Muhammad, Zhang, Fangfang, Ran, Yuanyuan, Liu, Zongjian, Wang, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314498/
https://www.ncbi.nlm.nih.gov/pubmed/34315538
http://dx.doi.org/10.1186/s13578-021-00661-x
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author Chen, Xuechai
Wang, Jianan
Tahir, Muhammad
Zhang, Fangfang
Ran, Yuanyuan
Liu, Zongjian
Wang, Juan
author_facet Chen, Xuechai
Wang, Jianan
Tahir, Muhammad
Zhang, Fangfang
Ran, Yuanyuan
Liu, Zongjian
Wang, Juan
author_sort Chen, Xuechai
collection PubMed
description Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RNA modification in eukaryotic cells, and the fate of m6A modified transcripts is controlled by m6A RNA binding proteins. m6A modification influences mRNA alternative splicing, stability, translation, and subcellular localization. Intriguingly, recent studies show that m6A RNA methylation could alter the expression of essential autophagy-related (ATG) genes and influence the autophagy function. Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases. In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including obesity, heart disease, azoospermatism or oligospermatism, intervertebral disc degeneration, and cancer. The comprehensive understanding of the m6A modification and autophagy interplay may help in interpreting their impact on human diseases and may aid in devising future therapeutic strategies.
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spelling pubmed-83144982021-07-28 Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases Chen, Xuechai Wang, Jianan Tahir, Muhammad Zhang, Fangfang Ran, Yuanyuan Liu, Zongjian Wang, Juan Cell Biosci Review Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RNA modification in eukaryotic cells, and the fate of m6A modified transcripts is controlled by m6A RNA binding proteins. m6A modification influences mRNA alternative splicing, stability, translation, and subcellular localization. Intriguingly, recent studies show that m6A RNA methylation could alter the expression of essential autophagy-related (ATG) genes and influence the autophagy function. Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases. In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including obesity, heart disease, azoospermatism or oligospermatism, intervertebral disc degeneration, and cancer. The comprehensive understanding of the m6A modification and autophagy interplay may help in interpreting their impact on human diseases and may aid in devising future therapeutic strategies. BioMed Central 2021-07-27 /pmc/articles/PMC8314498/ /pubmed/34315538 http://dx.doi.org/10.1186/s13578-021-00661-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Xuechai
Wang, Jianan
Tahir, Muhammad
Zhang, Fangfang
Ran, Yuanyuan
Liu, Zongjian
Wang, Juan
Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases
title Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases
title_full Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases
title_fullStr Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases
title_full_unstemmed Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases
title_short Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases
title_sort current insights into the implications of m6a rna methylation and autophagy interaction in human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314498/
https://www.ncbi.nlm.nih.gov/pubmed/34315538
http://dx.doi.org/10.1186/s13578-021-00661-x
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