Cargando…

Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

Detalles Bibliográficos
Autores principales:	Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J., Romero-Pérez, Laura, Wehweck, Fabienne S., Musa, Julian, Bestvater, Felix, Knott, Maximilian M. L., Hölting, Tilman L. B., Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314608/ https://www.ncbi.nlm.nih.gov/pubmed/34315482 http://dx.doi.org/10.1186/s12943-021-01393-9

Ejemplares similares

Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma
por: Dallmayer, Marlene, et al.
Publicado: (2019)

Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients
por: Sannino, Giuseppina, et al.
Publicado: (2019)

Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma
por: Cidre-Aranaz, Florencia, et al.
Publicado: (2022)

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies
por: Knott, Maximilian M. L., et al.
Publicado: (2020)

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
por: Marchetto, Aruna, et al.
Publicado: (2020)

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
por: Orth, Martin F., et al.
Publicado: (2020)

Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
por: Marchetto, Aruna, et al.
Publicado: (2020)

Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
por: Li, Jing, et al.
Publicado: (2021)

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
por: Ceranski, A. Katharina, et al.
Publicado: (2023)

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
por: Orth, Martin F., et al.
Publicado: (2022)

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets
por: Baldauf, Michaela C., et al.
Publicado: (2017)

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
por: Cidre-Aranaz, Florencia, et al.
Publicado: (2015)

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
por: Musa, Julian, et al.
Publicado: (2019)

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
por: Deng, Qu, et al.
Publicado: (2022)

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
por: Hölting, Tilman L. B., et al.
Publicado: (2022)

Ewing Sarcoma as Secondary Malignant Neoplasm—Epidemiological and Clinical Analysis of an International Trial Registry
por: Zöllner, Stefan K., et al.
Publicado: (2022)

Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma
por: Fuest, Sebastian, et al.
Publicado: (2022)

ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis
por: Pasello, Michela, et al.
Publicado: (2022)

Correction to: ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis
por: Pasello, Michela, et al.
Publicado: (2022)

Secondary Malignancies after Ewing Sarcoma—Epidemiological and Clinical Analysis of an International Trial Registry
por: Kaiser, Isabelle, et al.
Publicado: (2022)

Dynamic prediction of overall survival: a retrospective analysis on 979 patients with Ewing sarcoma from the German registry
por: Liu, Chuchu, et al.
Publicado: (2020)

Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma
por: Steinestel, Konrad, et al.
Publicado: (2019)

RRM1 *151A>T, RRM1 ‐756T>C, and RRM1 ‐585T>Gis associated with increased susceptibility of lung cancer in Chinese patients
por: Xu, Xiao‐Ling, et al.
Publicado: (2016)

The translational repressor 4E-BP1regulates RRM2 levels and functions as a tumor suppressor in Ewing Sarcoma Tumors
por: Goss, Kelli L., et al.
Publicado: (2020)

Primary and Metastatic Intracranial Ewing Sarcoma at Diagnosis: Retrospective International Study and Systematic Review
por: Haveman, Lianne M., et al.
Publicado: (2020)

The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma
por: Haveman, Lianne M., et al.
Publicado: (2019)

Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery
por: Bosma, S. E., et al.
Publicado: (2019)

Systematic identification of cancer-specific MHC-binding peptides with RAVEN
por: Baldauf, Michaela C., et al.
Publicado: (2018)

No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease
por: Thiel, U., et al.
Publicado: (2021)

Effect of Radiotherapy Dose on Outcome in Nonmetastatic Ewing Sarcoma
por: Kersting, Josephine, et al.
Publicado: (2023)

Correction to: No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease
por: Thiel, U., et al.
Publicado: (2021)

Differentially Expressed miRNAs in Ewing Sarcoma Compared to Mesenchymal Stem Cells: Low miR-31 Expression with Effects on Proliferation and Invasion
por: Karnuth, Bianca, et al.
Publicado: (2014)

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G
por: Spurny, Christian, et al.
Publicado: (2017)

Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo
por: Kirschner, Andreas, et al.
Publicado: (2017)

Localized Ewing sarcoma of the tibia
por: Kashima, Takeshi G, et al.
Publicado: (2013)

Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma
por: Berthold, Ruth, et al.
Publicado: (2022)

Utility of Integrated PET/MRI for the Primary Diagnostic Work-Up of Patients with Ewing Sarcoma: Preliminary Results
por: Chodyla, Michal, et al.
Publicado: (2022)

Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine
por: Jørgensen, Charlotte LT, et al.
Publicado: (2013)

Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition
por: Krepl, Miroslav, et al.
Publicado: (2017)

Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
por: Zöllner, Stefan K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f8c614qonkk2mbg3jh2719pcb9