A pancreas tumor derived organoid study: from drug screen to precision medicine

Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, and systemic therapies for PDAC generally lack efficacy. Thus, developing biomarkers for tr...

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Autores principales: Yao, Jia, Yang, Man, Atteh, Lawrence, Liu, Pinyan, Mao, Yongcui, Meng, Wenbo, Li, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314636/
https://www.ncbi.nlm.nih.gov/pubmed/34315500
http://dx.doi.org/10.1186/s12935-021-02044-1
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author Yao, Jia
Yang, Man
Atteh, Lawrence
Liu, Pinyan
Mao, Yongcui
Meng, Wenbo
Li, Xun
author_facet Yao, Jia
Yang, Man
Atteh, Lawrence
Liu, Pinyan
Mao, Yongcui
Meng, Wenbo
Li, Xun
author_sort Yao, Jia
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, and systemic therapies for PDAC generally lack efficacy. Thus, developing biomarkers for treatment guidance is urgently required. This review focuses on pancreatic tumor organoids (PTOs), which can mimic the characteristics of the original tumor in vitro. As a powerful tool with several applications, PTOs represent a new strategy for targeted therapy in pancreatic cancer and contribute to the advancement of the field of personalized medicine.
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spelling pubmed-83146362021-07-28 A pancreas tumor derived organoid study: from drug screen to precision medicine Yao, Jia Yang, Man Atteh, Lawrence Liu, Pinyan Mao, Yongcui Meng, Wenbo Li, Xun Cancer Cell Int Review Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, and systemic therapies for PDAC generally lack efficacy. Thus, developing biomarkers for treatment guidance is urgently required. This review focuses on pancreatic tumor organoids (PTOs), which can mimic the characteristics of the original tumor in vitro. As a powerful tool with several applications, PTOs represent a new strategy for targeted therapy in pancreatic cancer and contribute to the advancement of the field of personalized medicine. BioMed Central 2021-07-27 /pmc/articles/PMC8314636/ /pubmed/34315500 http://dx.doi.org/10.1186/s12935-021-02044-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yao, Jia
Yang, Man
Atteh, Lawrence
Liu, Pinyan
Mao, Yongcui
Meng, Wenbo
Li, Xun
A pancreas tumor derived organoid study: from drug screen to precision medicine
title A pancreas tumor derived organoid study: from drug screen to precision medicine
title_full A pancreas tumor derived organoid study: from drug screen to precision medicine
title_fullStr A pancreas tumor derived organoid study: from drug screen to precision medicine
title_full_unstemmed A pancreas tumor derived organoid study: from drug screen to precision medicine
title_short A pancreas tumor derived organoid study: from drug screen to precision medicine
title_sort pancreas tumor derived organoid study: from drug screen to precision medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314636/
https://www.ncbi.nlm.nih.gov/pubmed/34315500
http://dx.doi.org/10.1186/s12935-021-02044-1
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